Inhibitors of protein–protein interactions (PPIs): an analysis of scaffold choices and buried surface area
X Ran, JE Gestwicki - Current opinion in chemical biology, 2018 - Elsevier
Protein–protein interactions (PPI) were once considered 'undruggable', but clinical
successes, driven by advanced methods in drug discovery, have challenged that notion …
successes, driven by advanced methods in drug discovery, have challenged that notion …
Multifarious functions of the fragile X mental retardation protein
JK Davis, K Broadie - Trends in Genetics, 2017 - cell.com
Fragile X syndrome (FXS), a heritable intellectual and autism spectrum disorder (ASD),
results from the loss of Fragile X mental retardation protein (FMRP). This …
results from the loss of Fragile X mental retardation protein (FMRP). This …
Calcium sensors in neuronal function and dysfunction
Calcium signaling in neurons as in other cell types can lead to varied changes in cellular
function. Neuronal Ca2+ signaling processes have also become adapted to modulate the …
function. Neuronal Ca2+ signaling processes have also become adapted to modulate the …
Glioblastoma cells vampirize WNT from neurons and trigger a JNK/MMP signaling loop that enhances glioblastoma progression and neurodegeneration
Glioblastoma (GB) is the most lethal brain tumor, and Wingless (Wg)-related integration site
(WNT) pathway activation in these tumors is associated with a poor prognosis. Clinically, the …
(WNT) pathway activation in these tumors is associated with a poor prognosis. Clinically, the …
Modeling Fragile X Syndrome in Drosophila
Intellectual disability (ID) and autism are hallmarks of Fragile X Syndrome (FXS), a
hereditary neurodevelopmental disorder. The gene responsible for FXS is Fragile X Mental …
hereditary neurodevelopmental disorder. The gene responsible for FXS is Fragile X Mental …
[HTML][HTML] NCS-1 is a regulator of calcium signaling in health and disease
GR Boeckel, BE Ehrlich - Biochimica et Biophysica Acta (BBA)-Molecular …, 2018 - Elsevier
Abstract Neuronal Calcium Sensor-1 (NCS-1) is a highly conserved calcium binding protein
which contributes to the maintenance of intracellular calcium homeostasis and regulation of …
which contributes to the maintenance of intracellular calcium homeostasis and regulation of …
Calpain inhibitor and ibudilast rescue β cell functions in a cellular model of Wolfram syndrome
Wolfram syndrome is a rare multisystem disease characterized by childhood-onset diabetes
mellitus and progressive neurodegeneration. Most cases are attributed to pathogenic …
mellitus and progressive neurodegeneration. Most cases are attributed to pathogenic …
A preliminary, prospective study of peripheral neuropathy and cognitive function in patients with breast cancer during taxane therapy
EY Ibrahim, S Munshani, I Domenicano, R Rodwin… - Plos one, 2022 - journals.plos.org
Dramatic improvements in cancer survival have occurred in the last decade, but the quality
of life for many survivors is compromised due to severe, long-lasting, and often irreversible …
of life for many survivors is compromised due to severe, long-lasting, and often irreversible …
NCS1 overexpression restored mitochondrial activity and behavioral alterations in a zebrafish model of Wolfram syndrome
L Crouzier, EM Richard, C Diez, M Denus… - … Therapy-Methods & …, 2022 - cell.com
Wolfram syndrome (WS) is a rare neurodegenerative disease resulting in deafness, optic
atrophy, diabetes, and neurological disorders. Currently, no treatment is available for …
atrophy, diabetes, and neurological disorders. Currently, no treatment is available for …
An assessment of the translational relevance of Drosophila in drug discovery
K Papanikolopoulou, A Mudher… - Expert opinion on drug …, 2019 - Taylor & Francis
Introduction: Drosophila melanogaster offers a powerful expedient and economical system
with facile genetics. Because of the high sequence and functional conservation with human …
with facile genetics. Because of the high sequence and functional conservation with human …