Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …

Duchenne muscular dystrophy (DMD) is an X-linked muscle-wasting disease caused by the
loss of dystrophin. DMD is associated with muscle degeneration, necrosis, inflammation …

Western blotting has been used for protein analyses in a wide range of tissue samples for>
30 years. Fundamental to Western blotting success are a number of important …

Tubular aggregates are regular arrays of membrane tubules accumulating in muscle with
age. They are found as secondary features in several muscle disorders, including alcohol …

Duchenne muscular dystrophy (DMD) is caused by the absence of the dystrophin protein
and a properly functioning dystrophin-associated protein complex (DAPC) in muscle cells …

Abstract Store-operated Ca2+ entry (SOCE) in skeletal muscle involves signalling between
stromal-interacting molecule 1 (STIM1) in the sarcoplasmic reticulum (SR) and Ca2+ …

Muscular dystrophies are a group of diseases characterised by the primary wasting of
skeletal muscle, which compromises patient mobility and in the most severe cases originate …

Skeletal muscle contraction relies on both high-fidelity calcium (Ca2+) signals and robust
capacity for adenosine triphosphate (ATP) generation. Ca2+ release units (CRUs) are highly …

Abstract Store-operated Ca 2+ entry (SOCE) is a Ca 2+ entry mechanism activated by
depletion of intracellular Ca 2+ stores. In skeletal muscle, SOCE is mediated by an …

Muscular dystrophy (MD) refers to a clinically and genetically heterogeneous group of
degenerative muscle disorders characterized by progressive muscle wasting and often …