Technology of deep brain stimulation: current status and future directions

JK Krauss, N Lipsman, T Aziz, A Boutet… - Nature Reviews …, 2021 - nature.com
Deep brain stimulation (DBS) is a neurosurgical procedure that allows targeted circuit-based
neuromodulation. DBS is a standard of care in Parkinson disease, essential tremor and …

[HTML][HTML] Opportunities of connectomic neuromodulation

A Horn, MD Fox - Neuroimage, 2020 - Elsevier
The process of altering neural activity–neuromodulation–has long been used to treat
patients with brain disorders and answer scientific questions. Deep brain stimulation in …

Predicting optimal deep brain stimulation parameters for Parkinson's disease using functional MRI and machine learning

A Boutet, R Madhavan, GJB Elias, SE Joel… - Nature …, 2021 - nature.com
Commonly used for Parkinson's disease (PD), deep brain stimulation (DBS) produces
marked clinical benefits when optimized. However, assessing the large number of possible …

[HTML][HTML] Probing responses to deep brain stimulation with functional magnetic resonance imaging

A Loh, D Gwun, CT Chow, A Boutet, J Tasserie… - Brain stimulation, 2022 - Elsevier
Background Deep brain stimulation (DBS) is an established treatment for certain movement
disorders and has additionally shown promise for various psychiatric, cognitive, and seizure …

Subthalamic nucleus deep brain stimulation modulates 2 distinct neurocircuits

L Shen, C Jiang, CS Hubbard, J Ren, C He… - Annals of …, 2020 - Wiley Online Library
Objective Current understanding of the neuromodulatory effects of deep brain stimulation
(DBS) on large‐scale brain networks remains elusive, largely due to the lack of techniques …

Effect of device configuration and patient's body composition on the RF heating and nonsusceptibility artifact of deep brain stimulation implants during MRI at 1.5 T and …

B Bhusal, BT Nguyen, PP Sanpitak, J Vu… - Journal of Magnetic …, 2021 - Wiley Online Library
Background Patients with deep brain stimulation (DBS) implants have limited access to MRI
due to safety concerns associated with RF‐induced heating. Currently, MRI in these patients …

Structural connectivity predicts clinical outcomes of deep brain stimulation for Tourette syndrome

KA Johnson, G Duffley, DN Anderson, JL Ostrem… - Brain, 2020 - academic.oup.com
Deep brain stimulation may be an effective therapy for select cases of severe, treatment-
refractory Tourette syndrome; however, patient responses are variable, and there are no …

Improving safety of MRI in patients with deep brain stimulation devices

A Boutet, CT Chow, K Narang, GJB Elias, C Neudorfer… - Radiology, 2020 - pubs.rsna.org
MRI is a valuable clinical and research tool for patients undergoing deep brain stimulation
(DBS). However, risks associated with imaging DBS devices have led to stringent …

Safety and image quality at 7T MRI for deep brain stimulation systems: Ex vivo study with lead-only and full-systems

B Bhusal, J Stockmann, B Guerin, A Mareyam, J Kirsch… - Plos one, 2021 - journals.plos.org
Ultra-high field MRI at 7 T can produce much better visualization of sub-cortical structures
compared to lower field, which can greatly help target verification as well as overall …

3T MRI of rapid brain activity changes driven by subcallosal cingulate deep brain stimulation

GJB Elias, J Germann, A Boutet, A Loh, B Li… - Brain, 2022 - academic.oup.com
Deep brain stimulation targeting the subcallosal cingulate area, a hub with multiple axonal
projections, has shown therapeutic potential for treatment-resistant mood disorders. While …