There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has
many roles in female and male reproduction, as a neuropeptide in the central nervous …

Relaxin has vital physiological roles in pregnant rats, mice, and pigs. Relaxin promotes
growth and softening of the cervix, thus facilitating rapid delivery of live young. Relaxin also …

Pregnancy is a unique physiological condition of profound maternal renal and systemic
vasodilation. Our goal has been to unveil the reproductive hormones mediating this …

1. Relaxin is a peptide hormone of about 6000 Da belonging to the insulin family. Like
insulin, relaxin is composed by two disulfide-linked chains, termed the A and B chains, the B …

The kidneys and other nonreproductive organs vasodilate during early gestation; however,
the “pregnancy hormones” responsible for the profound vasodilation of the renal circulation …

Marked vasodilation in the kidney and other nonreproductive organs is one of the earliest
maternal adaptations to occur during pregnancy. Despite the recognition of this …

Abstract Relaxin, insulin-like peptide 3 (INSL3), relaxin-3, and INSL5 are the cognate
ligands for the relaxin family peptide (RXFP) receptors 1–4, respectively. RXFP1 activates …

Although substantial advances have been achieved in recent decades in the clinical
management of heart diseases, new therapies that provide better or additional efficacy with …

Relaxin is an approximately 6-kilodalton peptide hormone secreted by the corpus luteum,
and circulates in the maternal blood during pregnancy. Relaxin administration to awake …

Aims The preconditioning-like infarct-sparing and anti-inflammatory effects of the peptide
hormone relaxin following ischemic injury have been studied in the heart. Whether …