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Cysteine oxidation in proteins: structure, biophysics, and simulation
Cysteine side chains can exist in distinct oxidation states depending on the pH and redox
potential of the environment, and cysteine oxidation plays important yet complex regulatory …
potential of the environment, and cysteine oxidation plays important yet complex regulatory …
Predicting equilibrium distributions for molecular systems with deep learning
Advances in deep learning have greatly improved structure prediction of molecules.
However, many macroscopic observations that are important for real-world applications are …
However, many macroscopic observations that are important for real-world applications are …
Transfer learning in proteins: evaluating novel protein learned representations for bioinformatics tasks
A representation method is an algorithm that calculates numerical feature vectors for
samples in a dataset. Such vectors, also known as embeddings, define a relatively low …
samples in a dataset. Such vectors, also known as embeddings, define a relatively low …
ATLAS: protein flexibility description from atomistic molecular dynamics simulations
Dynamical behaviour is one of the most crucial protein characteristics. Despite the advances
in the field of protein structure resolution and prediction, analysis and prediction of protein …
in the field of protein structure resolution and prediction, analysis and prediction of protein …
[HTML][HTML] Sites of transcription initiation drive mRNA isoform selection
C Alfonso-Gonzalez, I Legnini, S Holec, L Arrigoni… - Cell, 2023 - cell.com
The generation of distinct messenger RNA isoforms through alternative RNA processing
modulates the expression and function of genes, often in a cell-type-specific manner. Here …
modulates the expression and function of genes, often in a cell-type-specific manner. Here …
Strikingly high activity of 15‐lipoxygenase towards di‐polyunsaturated arachidonoyl/adrenoyl‐phosphatidylethanolamines generates peroxidation signals of …
The vast majority of membrane phospholipids (PLs) include two asymmetrically positioned
fatty acyls: oxidizable polyunsaturated fatty acids (PUFA) attached predominantly at the sn2 …
fatty acyls: oxidizable polyunsaturated fatty acids (PUFA) attached predominantly at the sn2 …
Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor
AMPA glutamate receptors (AMPARs), the primary mediators of excitatory
neurotransmission in the brain, are either GluA2 subunit-containing and thus Ca2+ …
neurotransmission in the brain, are either GluA2 subunit-containing and thus Ca2+ …
Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants
S Moriyama, Y Anraku, S Taminishi, Y Adachi… - Nature …, 2023 - nature.com
SARS-CoV-2 Omicron subvariants have evolved to evade receptor-binding site (RBS)
antibodies that exist in diverse individuals as public antibody clones. We rationally selected …
antibodies that exist in diverse individuals as public antibody clones. We rationally selected …
Molecular mechanism of high-pressure processing regulates the aggregation of major royal jelly proteins
F Pan, X Li, T Tuersuntuoheti, W Wang, X Zheng… - Food …, 2023 - Elsevier
The aggregation behavior of major royal jelly proteins (MRJPs) significantly impacts their
quality and nutrient bioavailability, yet studies on their aggregate regulation are limited. This …
quality and nutrient bioavailability, yet studies on their aggregate regulation are limited. This …
Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators
Programmed ferroptotic death eliminates cells in all major organs and tissues with
imbalanced redox metabolism due to overwhelming iron-catalyzed lipid peroxidation under …
imbalanced redox metabolism due to overwhelming iron-catalyzed lipid peroxidation under …