An update on T-2 toxin and its modified forms: Metabolism, immunotoxicity mechanism, and human exposure assessment

Q Wu, Z Qin, K Kuca, L You, Y Zhao, A Liu… - Archives of …, 2020 - Springer
T-2 toxin is the most toxic trichothecene mycotoxin, and it exerts potent toxic effects,
including immunotoxicity, neurotoxicity, and reproductive toxicity. Recently, several novel …

Hypoxia, oxidative stress, and immune evasion: a trinity of the trichothecenes T-2 toxin and deoxynivalenol (DON)

L You, Y Zhao, K Kuca, X Wang, P Oleksak… - Archives of …, 2021 - Springer
T-2 toxin and deoxynivalenol (DON) are type A and B trichothecenes, respectively. They
widely occur as pollutants in food and crops and cause a series of toxicities, including …

A fluorescence aptasensor for the sensitive detection of T-2 toxin based on FRET by adjusting the surface electric potentials of UCNPs and MIL-101

X Zhao, Y Wang, J Li, B Huo, H Huang, J Bai… - Analytica Chimica …, 2021 - Elsevier
T-2 toxin is a class A trichothecene mycotoxin produced by Fusarium, which exhibits
genotoxic, cytotoxic, and immunotoxic effects in animals and humans. In this study, we …

T-2 toxin metabolism and its hepatotoxicity: New insights on the molecular mechanism and detoxification

W Song, Y Wang, T Huang, Y Liu, F Chen, Y Chen… - Environmental …, 2023 - Elsevier
T-2 toxin, a type A trichothecene, is a secondary metabolite produced by Fusarium poae,
Fusarium sporotrichioides, and Fusarium tricinctum. As the most toxic trichothecenes, T-2 …

Betulinic acid alleviates spleen oxidative damage induced by acute intraperitoneal exposure to T-2 toxin by activating Nrf2 and inhibiting MAPK signaling pathways

L Kong, L Zhu, X Yi, Y Huang, H Zhao, Y Chen, Z Yuan… - Antioxidants, 2021 - mdpi.com
T-2 toxin, which is mainly produced by specific strains of Fusarium in nature, can induce
immunotoxicity and oxidative stress, resulting in immune organ dysfunction and apoptosis …

Insights into the role of nucleotide methylation in metabolic-associated fatty liver disease

N Zhang, X Tian, T Yan, H Wang, D Zhang… - Frontiers in …, 2023 - frontiersin.org
Metabolic-associated fatty liver disease (MAFLD) is a chronic liver disease characterized by
fatty infiltration of the liver. In recent years, the MAFLD incidence rate has risen and emerged …

Hydrogel SERS chip with strong localized surface plasmon resonance for sensitive and rapid detection of T-2 toxin

M Chen, B Su, H Wu, Y Dai, T Chen, F Fu, Z Lin… - Talanta, 2024 - Elsevier
T-2 toxin is one of the naturally dangerous food contaminants, which is harmful to people
and animals. Because of its strong toxicity and wide distribution, it is vital to develop a rapid …

The impact of natural dietary compounds and food-borne mycotoxins on DNA methylation and cancer

T Ghazi, T Arumugam, A Foolchand, AA Chuturgoon - Cells, 2020 - mdpi.com
Cancer initiation and progression is an accumulation of genetic and epigenetic
modifications. DNA methylation is a common epigenetic modification that regulates gene …

Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice

L Huang, L Zhu, Z Ou, C Ma, L Kong, Y Huang… - International …, 2021 - Elsevier
Betulinic acid (BA) is a pentacyclic triterpenoid compound with potential antioxidant and anti-
inflammatory effects. In this study, T-2 toxin was injected intraperitoneally in mice to establish …

[HTML][HTML] T-2 toxin triggers lipid metabolism disorder and oxidative stress in liver of ducks

K An, B Shi, X Lv, Y Liu, Z **a - Ecotoxicology and Environmental Safety, 2024 - Elsevier
Abstract T-2 toxin (T-2) is a highly toxic mycotoxin that threatens organism health, yet its
hepatoxicity on ducks remains unknown. The present study aimed to assess the hepatoxicity …