Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

Abstract Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …

Ferroptosis is a type of regulated cell death characterized by intracellular accumulation of
iron and reactive oxygen species, inhibition of system Xc-, glutathione depletion …

Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …

Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-
dependent, lipid peroxidation-driven membrane destruction that can be inhibited by …

Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Background Sepsis is a fatal disease with a high rate of morbidity and mortality, during
which acute lung injury is the earliest and most serious complication. Injury of pulmonary …

Ferroptosis is an iron-catalysed form of regulated cell death, which is critically dependent on
phospholipid peroxidation of cellular membranes. Ferrostatin 1 was one of the first synthetic …

Ferroptosis is an iron-dependent and lipid peroxidation-driven cell death cascade, occurring
when there is an imbalance of redox homeostasis in the cell. Nuclear factor erythroid 2 …

Disruptions in metal balance can trigger a synergistic interplay of cuproptosis and
ferroptosis, offering promising solutions to enduring challenges in oncology. Here, we have …