[HTML][HTML] Schiff bases and their possible therapeutic applications: A review
Schiff base (SB) represents a category of organic compounds in which a nitrogen atom with
a double bond maintains its stereochemistry. The long history of Schiff base has been …
a double bond maintains its stereochemistry. The long history of Schiff base has been …
[PDF][PDF] Biological applications of Schiff bases: An overview
Schiff bases are the compounds containing the azomethine group (-HC= N-). They are
formed by the condensation of ketones or aldehydes with a primary amine. Formation of …
formed by the condensation of ketones or aldehydes with a primary amine. Formation of …
Exploration of 1, 2, 3-triazole linked benzenesulfonamide derivatives as isoform selective inhibitors of human carbonic anhydrase
Abstract A novel series of 1, 2, 3-triazole benzenesulfonamide substituted 1, 3-
dioxoisoindolin-5-carboxylate (7a-l) inhibitors of human α-carbonic anhydrase (hCA) was …
dioxoisoindolin-5-carboxylate (7a-l) inhibitors of human α-carbonic anhydrase (hCA) was …
Discovery of novel benzenesulfonamides incorporating 1, 2, 3-triazole scaffold as carbonic anhydrase I, II, IX, and XII inhibitors
Sulfonamides are among the most promising potential inhibitors for carbonic anhydrases
(CAs), which are pharmaceutically relevant targets for treating several disease conditions …
(CAs), which are pharmaceutically relevant targets for treating several disease conditions …
Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, α-glycosidase, and carbonic anhydrase inhibitors of novel …
Some metabolic enzyme inhibitors can be used in the treatment of many diseases.
Therefore, synthesis and determination of alternative inhibitors are essential. In this study …
Therefore, synthesis and determination of alternative inhibitors are essential. In this study …
Cytotoxic effect, enzyme inhibition, and in silico studies of some novel N-substituted sulfonyl amides incorporating 1,3,4-oxadiazol structural motif
The acetylcholinesterase and carbonic anhydrase inhibitors (AChEIs and h CAIs) remain
key therapeutic agents for many bioactivities such as anti-Alzheimer and antiobesity …
key therapeutic agents for many bioactivities such as anti-Alzheimer and antiobesity …
Design, synthesis, characterization, in vitro and in silico evaluation of novel imidazo [2, 1-b][1, 3, 4] thiadiazoles as highly potent acetylcholinesterase and non …
Imidazole and thiadiazole derivatives display an extensive application in pharmaceutical
chemistry, and they have been investigated as bioactive molecules for medicinal chemistry …
chemistry, and they have been investigated as bioactive molecules for medicinal chemistry …
Design, synthesis, biological evaluation and molecular docking studies of novel 1H-1, 2, 3-Triazole derivatives as potent inhibitors of carbonic anhydrase …
Triazole compounds have garnered significant interest due to their wide range of
pharmacological activities and ease of synthesis. Click chemistry is a synthetic method …
pharmacological activities and ease of synthesis. Click chemistry is a synthetic method …
Design, synthesis, and biological activity of novel dithiocarbamate‐methylsulfonyl hybrids as carbonic anhydrase inhibitors
Carbonic anhydrase (CA) enzymes are involved in many physiological events. These
enzymes, which contain Zn2+ in their structure, can be easily inhibited by dithiocarbamate …
enzymes, which contain Zn2+ in their structure, can be easily inhibited by dithiocarbamate …
Molecular docking and inhibition studies of vulpinic, carnosic and usnic acids on polyol pathway enzymes
Aldose reductase (AR) and sorbitol dehydrogenase (SDH) are important enzymes of the
polyol pathway. In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) …
polyol pathway. In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) …