Self-maintaining resident macrophages populate all mammalian organs. In addition to their
role as immune sentinels, macrophages perform day-to-day functions essential to tissue …

The presentation of exogenous antigens on MHC class I molecules, known as cross-
presentation, is essential for the initiation of CD8+ T cell responses. In vivo, cross …

Dendritic cells, macrophages and B cells are regarded as the classical antigen-presenting
cells of the immune system. However, in recent years, there has been a rapid increase in the …

Dendritic cells (DC) are professional antigen presenting cells comprising a variety of
subsets, as either resident or migrating cells, in lymphoid and non-lymphoid organs. In the …

The differentiation of bone marrow–derived progenitor cells into monocytes, tissue
macrophages and some dendritic cell (DC) subtypes requires the growth factor CSF1 and its …

Immune cell populations in the skin are predominantly comprised of dendritic cells (DCs)
and macrophages. A lack of consensus regarding how to define these cell types has …

Human skin and its immune cells provide essential protection of the human body from injury
and infection. Recent studies reinforce the importance of keratinocytes as sensors of danger …

Dendritic cells (DCs) are essential mediators of innate and adaptive immune responses.
Study of these critical cells has been complicated by their similarity to other hematopoietic …

Our understanding of conventional dendritic cell (cDC) development and the functional
specializations of distinct subsets in the peripheral tissues has increased greatly in recent …

The skin is a barrier site that is exposed to a wide variety of potential pathogens. As in other
organs, pathogens that invade the skin are recognized by pattern-recognition receptors …