Neurodegenerative disorders (NDs) such as Alzheimer's disease, Parkinson's disease,
Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis are severe and …

The complex pathophysiology of Alzheimer's disease (AD) poses challenges for the
development of therapies. Recently, neuroinflammation has been identified as a key …

Background Alterations of blood-brain barrier (BBB) and blood-spinal cord barrier have
been documented in various animal models of neurodegenerative diseases and in patients …

Cigarette smoke (CS), an indoor environmental pollution, is an environmental risk factor for
diverse neurological disorders. However, the neurotoxicological effects and mechanisms of …

Background Cerebrospinal fluid (CSF) β2-microglobulin (β2M) has been demonstrated as
an important factor in β-amyloid (Aβ) neurotoxicity and a potential target for Alzheimer's …

Acetylcholinesterase (AChE) is a pivotal enzyme in nerve conduction, controlling its activity
with its inhibitor (AChEI) is crucial for the treatment of Alzheimer's disease (AD). However …

Viruses pose a significant challenge and threat to human health, as demonstrated by the
current COVID-19 pandemic. Neurodegeneration, particularly in the case of Alzheimer's …

Introduction Marfan Syndrome (MFS) is a connective tissue disorder due to mutations in
fibrillin-1 (Fbn1), where a Fbn1 missense mutation (Fbn1 C1039G/+) can result in systemic …

Abstract Background The Blood-Brain Barrier (BBB) is a complex and dynamic interface that
regulates the exchange of molecules and cells between the blood and the central nervous …

Researchers have placed engineered or natural tissues within microfluidic chips originating
the so-called organ-on-a-chip (OoC) devices. With this technology, organ models can be …