Mitochondrial function as a therapeutic target in heart failure
Heart failure is a pressing worldwide public-health problem with millions of patients having
worsening heart failure. Despite all the available therapies, the condition carries a very poor …
worsening heart failure. Despite all the available therapies, the condition carries a very poor …
Human cardiac metabolism
The heart is the most metabolically active organ in the human body, and cardiac metabolism
has been studied for decades. However, the bulk of studies have focused on animal models …
has been studied for decades. However, the bulk of studies have focused on animal models …
Myocardial and systemic inflammation in acute stress-induced (Takotsubo) cardiomyopathy
C Scally, H Abbas, T Ahearn, J Srinivasan… - Circulation, 2019 - ahajournals.org
Background: Acute stress-induced (takotsubo) cardiomyopathy can result in a heart failure
phenotype with a prognosis comparable with that of myocardial infarction. In this study, we …
phenotype with a prognosis comparable with that of myocardial infarction. In this study, we …
Persistent long-term structural, functional, and metabolic changes after stress-induced (Takotsubo) cardiomyopathy
Background: Takotsubo cardiomyopathy is an increasingly recognized acute heart failure
syndrome precipitated by intense emotional stress. Although there is an apparent rapid and …
syndrome precipitated by intense emotional stress. Although there is an apparent rapid and …
Creatine and creatinine metabolism
The goal of this review is to present a comprehensive survey of the many intriguing facets of
creatine (Cr) and creatinine metabolism, encompassing the pathways and regulation of Cr …
creatine (Cr) and creatinine metabolism, encompassing the pathways and regulation of Cr …
Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with 31P-SLOOP …
M Beer, T Seyfarth, J Sandstede, W Landschütz… - Journal of the American …, 2002 - jacc.org
Objectives: The purpose of the present study was to measure absolute concentrations of
phosphocreatine (PCr) and adenosine triphosphate (ATP) in normal, hypertrophied, and …
phosphocreatine (PCr) and adenosine triphosphate (ATP) in normal, hypertrophied, and …
Cardiac structure and function are altered in adults with non-alcoholic fatty liver disease
Background & Aims Non-alcoholic fatty liver disease (NAFLD) is associated with a twofold
greater risk of develo** cardiovascular disease. Despite this, little is known about the …
greater risk of develo** cardiovascular disease. Despite this, little is known about the …
Antioxidant treatment improves in vivo cardiac and skeletal muscle bioenergetics in patients with Friedreich's ataxia
R Lodi, PE Hart, B Rajagopalan, DJ Taylor… - Annals of …, 2001 - Wiley Online Library
Friedreich's ataxia (FA) is the most common form of autosomal recessive spinocerebellar
ataxia and is often associated with a cardiomyopathy. The disease is caused by an …
ataxia and is often associated with a cardiomyopathy. The disease is caused by an …
Noninvasive Study of High-Energy Phosphate Metabolism in Human Heart by Depth-Resolved 31P NMR Spectroscopy
Phosphorus-31 nuclear magnetic resonance (NMR) spectra showing the relative
concentrations of high-energy phosphate metabolites have been recorded noninvasively …
concentrations of high-energy phosphate metabolites have been recorded noninvasively …
[HTML][HTML] Left ventricular dysfunction after mitral valve repair—the fallacy of “normal” preoperative myocardial function
Objective A proportion of patients experience a decrease in left ventricular (LV) ejection
fraction (EF) after mitral valve repair; however, predictors and long-term consequences …
fraction (EF) after mitral valve repair; however, predictors and long-term consequences …