Stem cell therapy is being intensely investigated within the last years. Expectations are high
regarding mesenchymal stem cell (MSC) treatment in translational medicine. However …

Mesenchymal stem/stromal cell (MSC)-based therapeutics is already available for treatment
of a range of diseases or medical conditions. Autologous or allogeneic MSCs obtained from …

No effective drug treatments are available for coronavirus disease 2019 (COVID-19). Host-
directed therapies targeting the underlying aberrant immune responses leading to …

Knee osteoarthritis (OA) is a leading cause of pain and disability. Although conventional
treatments show modest benefits, pilot and phase I/II trials with bone marrow (BM) and …

For several decades, multipotent mesenchymal stromal cells (MSCs) have been extensively
studied for their therapeutic potential across a wide range of diseases. In the preclinical …

Wound healing is an important function of skin; however, after significant skin injury (burns)
or in certain dermatological pathologies (chronic wounds), this important process can be …

The insufficient and unspecific target of traditional therapeutic approaches in cancer
treatment often leads to therapy resistance and cancer recurrence. Over the past decades …

Extracellular vesicles (EVs), including exosomes and microvesicles, derived from
mesenchymal stem/stromal cells (MSCs) exert similar effects as their parental cells, and are …

Background Immunoregulatory capacity of mesenchymal stem cells (MSC) is triggered by
the inflammatory environment, which changes during tissue repair. Macrophages are …

Summary 2018 was the year of the first marketing authorization of an allogeneic stem cell
therapy by the European Medicines Agency. The authorization concerns the use of …