Overcoming blood–brain barrier transport: Advances in nanoparticle-based drug delivery strategies

S Ding, AI Khan, X Cai, Y Song, Z Lyu, D Du, P Dutta… - Materials today, 2020 - Elsevier
The blood–brain barrier (BBB), a unique structure in the central nervous system (CNS),
protects the brain from bloodborne pathogens by its excellent barrier properties …

Nanocarriers as potential drug delivery candidates for overcoming the blood–brain barrier: challenges and possibilities

J Ahlawat, G Guillama Barroso, S Masoudi Asil… - Acs Omega, 2020 - ACS Publications
The design of a drug that successfully overcomes the constraints imposed by the blood–
brain barrier (BBB, which acts as a gatekeeper to the entry of substances into the brain) …

Functionalized nanomaterials capable of crossing the blood–brain barrier

S Zha, H Liu, H Li, H Li, KL Wong, AH All - ACS nano, 2024 - ACS Publications
The blood–brain barrier (BBB) is a specialized semipermeable structure that highly
regulates exchanges between the central nervous system parenchyma and blood vessels …

[HTML][HTML] Nanocarriers as a powerful vehicle to overcome blood-brain barrier in treating neurodegenerative diseases: Focus on recent advances

X Niu, J Chen, J Gao - Asian journal of pharmaceutical sciences, 2019 - Elsevier
Neurodegenerative diseases including Alzheimer's disease, Parkinson's disease,
Huntington disease and amyotrophic lateral sclerosis throw a heavy burden on families and …

Nano-therapies for glioblastoma treatment

E Alphandéry - Cancers, 2020 - mdpi.com
Traditional anti-cancer treatments are inefficient against glioblastoma, which remains one of
the deadliest and most aggressive cancers. Nano-drugs could help to improve this situation …

Thermoresponsive polymer assemblies: from molecular design to theranostics application

SL Qiao, M Mamuti, HW An, H Wang - Progress in Polymer Science, 2022 - Elsevier
Molecule self-assembly is a ubiquitous phenomenon and a key driving force for constructing
nanostructures with diverse morphology and controllable size. Recently, interests in …

Stimuli-responsive polymeric nanocarriers accelerate on-demand drug release to combat glioblastoma

M Ismail, Y Wang, Y Li, J Liu, M Zheng… - Biomacromolecules, 2024 - ACS Publications
Glioblastoma multiforme (GBM) is a highly malignant brain tumor with a poor prognosis and
limited treatment options. Drug delivery by stimuli-responsive nanocarriers holds great …

[HTML][HTML] Understanding molecular mechanisms of biologics drug delivery and stability from NMR spectroscopy

P Phyo, X Zhao, AC Templeton, W Xu… - Advanced Drug Delivery …, 2021 - Elsevier
Protein therapeutics carry inherent limitations of membrane impermeability and structural
instability, despite their predominant role in the modern pharmaceutical market. Effective …

Stimuli-responsive lipid-based magnetic nanovectors increase apoptosis in glioblastoma cells through synergic intracellular hyperthermia and chemotherapy

C Tapeinos, A Marino, M Battaglini, S Migliorin… - Nanoscale, 2019 - pubs.rsc.org
In this study, taking into consideration the limitations of current treatments of glioblastoma
multiforme, we fabricated a biomimetic lipid-based magnetic nanovector with a good loading …

Nanoparticle-based diagnostic and therapeutic systems for brain tumors

X Wu, H Yang, W Yang, X Chen, J Gao… - Journal of Materials …, 2019 - pubs.rsc.org
Brain tumors, especially the most prevalent and aggressive glioblastoma, remain among the
deadliest of all types of cancer due to inefficient theranostic options. They have a limited …