Overcoming blood–brain barrier transport: Advances in nanoparticle-based drug delivery strategies
The blood–brain barrier (BBB), a unique structure in the central nervous system (CNS),
protects the brain from bloodborne pathogens by its excellent barrier properties …
protects the brain from bloodborne pathogens by its excellent barrier properties …
Nanocarriers as potential drug delivery candidates for overcoming the blood–brain barrier: challenges and possibilities
The design of a drug that successfully overcomes the constraints imposed by the blood–
brain barrier (BBB, which acts as a gatekeeper to the entry of substances into the brain) …
brain barrier (BBB, which acts as a gatekeeper to the entry of substances into the brain) …
Functionalized nanomaterials capable of crossing the blood–brain barrier
The blood–brain barrier (BBB) is a specialized semipermeable structure that highly
regulates exchanges between the central nervous system parenchyma and blood vessels …
regulates exchanges between the central nervous system parenchyma and blood vessels …
[HTML][HTML] Nanocarriers as a powerful vehicle to overcome blood-brain barrier in treating neurodegenerative diseases: Focus on recent advances
X Niu, J Chen, J Gao - Asian journal of pharmaceutical sciences, 2019 - Elsevier
Neurodegenerative diseases including Alzheimer's disease, Parkinson's disease,
Huntington disease and amyotrophic lateral sclerosis throw a heavy burden on families and …
Huntington disease and amyotrophic lateral sclerosis throw a heavy burden on families and …
Nano-therapies for glioblastoma treatment
E Alphandéry - Cancers, 2020 - mdpi.com
Traditional anti-cancer treatments are inefficient against glioblastoma, which remains one of
the deadliest and most aggressive cancers. Nano-drugs could help to improve this situation …
the deadliest and most aggressive cancers. Nano-drugs could help to improve this situation …
Thermoresponsive polymer assemblies: from molecular design to theranostics application
SL Qiao, M Mamuti, HW An, H Wang - Progress in Polymer Science, 2022 - Elsevier
Molecule self-assembly is a ubiquitous phenomenon and a key driving force for constructing
nanostructures with diverse morphology and controllable size. Recently, interests in …
nanostructures with diverse morphology and controllable size. Recently, interests in …
Stimuli-responsive polymeric nanocarriers accelerate on-demand drug release to combat glioblastoma
Glioblastoma multiforme (GBM) is a highly malignant brain tumor with a poor prognosis and
limited treatment options. Drug delivery by stimuli-responsive nanocarriers holds great …
limited treatment options. Drug delivery by stimuli-responsive nanocarriers holds great …
[HTML][HTML] Understanding molecular mechanisms of biologics drug delivery and stability from NMR spectroscopy
Protein therapeutics carry inherent limitations of membrane impermeability and structural
instability, despite their predominant role in the modern pharmaceutical market. Effective …
instability, despite their predominant role in the modern pharmaceutical market. Effective …
Stimuli-responsive lipid-based magnetic nanovectors increase apoptosis in glioblastoma cells through synergic intracellular hyperthermia and chemotherapy
In this study, taking into consideration the limitations of current treatments of glioblastoma
multiforme, we fabricated a biomimetic lipid-based magnetic nanovector with a good loading …
multiforme, we fabricated a biomimetic lipid-based magnetic nanovector with a good loading …
Nanoparticle-based diagnostic and therapeutic systems for brain tumors
X Wu, H Yang, W Yang, X Chen, J Gao… - Journal of Materials …, 2019 - pubs.rsc.org
Brain tumors, especially the most prevalent and aggressive glioblastoma, remain among the
deadliest of all types of cancer due to inefficient theranostic options. They have a limited …
deadliest of all types of cancer due to inefficient theranostic options. They have a limited …