Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on
health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast …

RNA uridylation is a potent and widespread posttranscriptional regulator of gene
expression. RNA uridylation has been detected in a range of eukaryotes including …

MicroRNAs (miRNAs) broadly regulate gene expression through association with Argonaute
(Ago), which also protects miRNAs from degradation. However, miRNA stability is known to …

The uridyl transferases TUT4 and TUT7 (collectively called TUT4 (7)) switch between two
modes of activity, either promoting expression of let-7 microRNA (monoU) or marking it for …

In Trypanosoma brucei, most mitochondrial mRNA s undergo internal changes by RNA
editing and 3′ end modifications. The temporally separated and functionally distinct …

In Trypanosoma brucei, most mitochondrial mRNAs undergo editing, and 3′ adenylation
and uridylation. The internal sequence changes and terminal extensions are coordinated …

Nucleic acid therapeutics have become increasingly recognized in recent years for their
capability to target both coding and non-coding sequences. Several types of nucleic acid …

Many polymerases and other proteins are endowed with a catalytic domain belonging to the
nucleotidyltransferase fold, which has also been deemed the non-canonical palm domain, in …

Abstract Non-templated 3′-uridylation of RNAs has emerged as an important mechanism
for regulating the processing, stability and biological function of eukaryotic transcripts. In …

Although recognized earlier as subcellular entities by microscopists, mitochondria have
been the subject of functional studies since 1922, when their biochemical similarities with …