The fungal cell wall: structure, biosynthesis, and function

NAR Gow, JP Latge, CA Munro - Microbiology spectrum, 2017 - Am Soc Microbiol
The molecular composition of the cell wall is critical for the biology and ecology of each
fungal species. Fungal walls are composed of matrix components that are embedded and …

Image-based profiling for drug discovery: due for a machine-learning upgrade?

SN Chandrasekaran, H Ceulemans, JD Boyd… - Nature Reviews Drug …, 2021 - nature.com
Image-based profiling is a maturing strategy by which the rich information present in
biological images is reduced to a multidimensional profile, a collection of extracted image …

A global genetic interaction network maps a wiring diagram of cellular function

M Costanzo, B VanderSluis, EN Koch, A Baryshnikova… - Science, 2016 - science.org
INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …

Plant phenylalanine/tyrosine ammonia-lyases

J Barros, RA Dixon - Trends in plant science, 2020 - cell.com
Aromatic amino acid deaminases are key enzymes mediating carbon flux from primary to
secondary metabolism in plants. Recent studies have uncovered a tyrosine ammonia-lyase …

[HTML][HTML] High value valorization of lignin as environmental benign antimicrobial

M Chen, Y Li, H Liu, D Zhang, QS Shi, XQ Zhong… - Materials Today Bio, 2023 - Elsevier
Lignin is a natural aromatic polymer of p-hydroxyphenylpropanoids with various biological
activities. Noticeably, plants have made use of lignin as biocides to defend themselves from …

The fungal cell wall as a target for the development of new antifungal therapies

JCG Cortés, MÁ Curto, VSD Carvalho, P Pérez… - Biotechnology …, 2019 - Elsevier
In the past three decades invasive mycoses have globally emerged as a persistent source of
healthcare-associated infections. The cell wall surrounding the fungal cell opposes the …

Applications in image-based profiling of perturbations

JC Caicedo, S Singh, AE Carpenter - Current opinion in biotechnology, 2016 - Elsevier
Highlights•Image-based profiling uses hundreds of measurements of cell morphology from
images.•Samples with similar phenotypes are grouped based on this unbiased, quantitative …

Inhibiting stearoyl-CoA desaturase ameliorates α-synuclein cytotoxicity

BM Vincent, DF Tardiff, JS Piotrowski, R Aron… - Cell reports, 2018 - cell.com
The lack of disease-modifying treatments for neurodegenerative disease stems in part from
our rudimentary understanding of disease mechanisms and the paucity of targets for …

Modes‐of‐action of antifungal compounds: Stressors and (target‐site‐specific) toxins, toxicants, or toxin–stressors

D Noel, JE Hallsworth, E Gelhaye… - Microbial …, 2023 - Wiley Online Library
Fungi and antifungal compounds are relevant to the United Nation's Sustainable
Development Goals. However, the modes‐of‐action of antifungals—whether they are …

Antifungal activities of wood extractives

N Valette, T Perrot, R Sormani, E Gelhaye… - Fungal Biology …, 2017 - Elsevier
Extractives are non-structural wood molecules that represent a minor fraction in wood.
However, they are source of diverse molecules putatively bioactive. Inhibition of fungal …