Therapeutic targeting of the hypoxic tumour microenvironment
Hypoxia is prevalent in human tumours and contributes to microenvironments that shape
cancer evolution and adversely affect therapeutic outcomes. Historically, two different …
cancer evolution and adversely affect therapeutic outcomes. Historically, two different …
Artificial intelligence in radiation oncology
Artificial intelligence (AI) has the potential to fundamentally alter the way medicine is
practised. AI platforms excel in recognizing complex patterns in medical data and provide a …
practised. AI platforms excel in recognizing complex patterns in medical data and provide a …
Clinical integration of machine learning for curative-intent radiation treatment of patients with prostate cancer
Abstract Machine learning (ML) holds great promise for impacting healthcare delivery;
however, to date most methods are tested in 'simulated'environments that cannot …
however, to date most methods are tested in 'simulated'environments that cannot …
Metrics to evaluate the performance of auto-segmentation for radiation treatment planning: A critical review
Advances in artificial intelligence-based methods have led to the development and
publication of numerous systems for auto-segmentation in radiotherapy. These systems …
publication of numerous systems for auto-segmentation in radiotherapy. These systems …
Expanding global access to radiotherapy
Radiotherapy is a critical and inseparable component of comprehensive cancer treatment
and care. For many of the most common cancers in low-income and middle-income …
and care. For many of the most common cancers in low-income and middle-income …
Automation in intensity modulated radiotherapy treatment planning—a review of recent innovations
Radiotherapy treatment planning of complex radiotherapy techniques, such as intensity
modulated radiotherapy and volumetric modulated arc therapy, is a resource-intensive …
modulated radiotherapy and volumetric modulated arc therapy, is a resource-intensive …
Image-guided radiotherapy: from current concept to future perspectives
DA Jaffray - Nature reviews Clinical oncology, 2012 - nature.com
Radiotherapy is a highly effective, targeted therapy for the management of cancer.
Technological innovations have enabled the direct integration of imaging technology into …
Technological innovations have enabled the direct integration of imaging technology into …
Clinical development of new drug–radiotherapy combinations
RA Sharma, R Plummer, JK Stock… - Nature reviews Clinical …, 2016 - nature.com
In countries with the best cancer outcomes, approximately 60% of patients receive
radiotherapy as part of their treatment, which is one of the most cost-effective cancer …
radiotherapy as part of their treatment, which is one of the most cost-effective cancer …
Prognostic Significance of p16INK4A and Human Papillomavirus in Patients With Oropharyngeal Cancer Treated on TROG 02.02 Phase III Trial
Purpose To determine the prognostic importance of p16 and human papillomavirus (HPV) in
patients with oropharyngeal cancer treated on a phase III concurrent chemoradiotherapy …
patients with oropharyngeal cancer treated on a phase III concurrent chemoradiotherapy …
Addition of metformin to concurrent chemoradiation in patients with locally advanced non–small cell lung cancer: The NRG-LU001 phase 2 randomized clinical trial
Importance Non–small cell lung cancer (NSCLC) has relatively poor outcomes. Metformin
has significant data supporting its use as an antineoplastic agent. Objective To compare …
has significant data supporting its use as an antineoplastic agent. Objective To compare …