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Steering cell migration: lamellipodium dynamics and the regulation of directional persistence
Membrane protrusions at the leading edge of cells, known as lamellipodia, drive cell
migration in many normal and pathological situations. Lamellipodial protrusion is powered …
migration in many normal and pathological situations. Lamellipodial protrusion is powered …
Actin assembly mechanisms at a glance
The actin cytoskeleton and associated motor proteins provide the driving forces for
establishing the astonishing morphological diversity and dynamics of mammalian cells …
establishing the astonishing morphological diversity and dynamics of mammalian cells …
EMT, the cytoskeleton, and cancer cell invasion
M Yilmaz, G Christofori - Cancer and Metastasis Reviews, 2009 - Springer
The metastatic process, ie the dissemination of cancer cells throughout the body to seed
secondary tumors at distant sites, requires cancer cells to leave the primary tumor and to …
secondary tumors at distant sites, requires cancer cells to leave the primary tumor and to …
Rho GTPases: biochemistry and biology
AB Jaffe, A Hall - Annu. Rev. Cell Dev. Biol., 2005 - annualreviews.org
Approximately one percent of the human genome encodes proteins that either regulate or
are regulated by direct interaction with members of the Rho family of small GTPases …
are regulated by direct interaction with members of the Rho family of small GTPases …
A nucleator arms race: cellular control of actin assembly
For over a decade, the actin-related protein 2/3 (ARP2/3) complex, a handful of nucleation-
promoting factors and formins were the only molecules known to directly nucleate actin …
promoting factors and formins were the only molecules known to directly nucleate actin …
Rho GTPases and their role in organizing the actin cytoskeleton
ST Sit, E Manser - Journal of cell science, 2011 - journals.biologists.com
Cells receive extracellular stimuli in various ways: in the form of soluble molecules (growth
factors, cytokines and hormones) that interact with cell-surface receptors; from adhesive …
factors, cytokines and hormones) that interact with cell-surface receptors; from adhesive …
Regulation of actin filament assembly by Arp2/3 complex and formins
TD Pollard - Annu. Rev. Biophys. Biomol. Struct., 2007 - annualreviews.org
This review summarizes what is known about the biochemical and biophysical mechanisms
that initiate the assembly of actin filaments in cells. Assembly and disassembly of these …
that initiate the assembly of actin filaments in cells. Assembly and disassembly of these …
Regulation of actin assembly associated with protrusion and adhesion in cell migration
C Le Clainche, MF Carlier - Physiological reviews, 2008 - journals.physiology.org
To migrate, a cell first extends protrusions such as lamellipodia and filopodia, forms
adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this …
adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this …
The WASP–WAVE protein network: connecting the membrane to the cytoskeleton
Wiskott–Aldrich syndrome protein (WASP) and WASP-family verprolin-homologous protein
(WAVE) family proteins are scaffolds that link upstream signals to the activation of the …
(WAVE) family proteins are scaffolds that link upstream signals to the activation of the …
The role of the Rho GTPases in neuronal development
EE Govek, SE Newey, L Van Aelst - Genes & development, 2005 - genesdev.cshlp.org
Our brain serves as a center for cognitive function and neurons within the brain relay and
store information about our surroundings and experiences. Modulation of this complex …
store information about our surroundings and experiences. Modulation of this complex …