Mitochondrial dysfunction and biogenesis in neurodegenerative diseases: pathogenesis and treatment
Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and
characterized by the progressive degeneration of the function and structure of the central …
characterized by the progressive degeneration of the function and structure of the central …
Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
Mitochondria as potential targets in Alzheimer disease therapy: an update
G Cenini, W Voos - Frontiers in pharmacology, 2019 - frontiersin.org
Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that
affects mostly the elderly population. At the moment, no effective treatments are available in …
affects mostly the elderly population. At the moment, no effective treatments are available in …
Biochemistry of mitochondrial coenzyme Q biosynthesis
Coenzyme Q (CoQ, ubiquinone) is a redox-active lipid produced across all domains of life
that functions in electron transport and oxidative phosphorylation and whose deficiency …
that functions in electron transport and oxidative phosphorylation and whose deficiency …
Role of reactive oxygen species in the progression of Alzheimer's disease
Highlights•Oxidative stress is an etiopathogenic event upstream to Aβ-plaques and
neurofibrillary tangles leading to Alzheimer's disease.•Unquenched ROS perturb the …
neurofibrillary tangles leading to Alzheimer's disease.•Unquenched ROS perturb the …
Mitochondrial diseases of the brain
Neurodegenerative disorders are debilitating diseases of the brain, characterized by
behavioral, motor and cognitive impairments. Ample evidence underpins mitochondrial …
behavioral, motor and cognitive impairments. Ample evidence underpins mitochondrial …
Linking oxidative stress and proteinopathy in Alzheimer's disease
Proteinopathy and excessive production of reactive oxygen species (ROS), which are the
principal features observed in the Alzheimer's disease (AD) brain, contribute to neuronal …
principal features observed in the Alzheimer's disease (AD) brain, contribute to neuronal …
Statins use in Alzheimer disease: bane or boon from frantic search and narrative review
Alzheimer's disease (AD) was used to describe pre-senile dementia to differentiate it from
senile dementia, which develops in the adult age group of more than 65 years. AD is …
senile dementia, which develops in the adult age group of more than 65 years. AD is …
[HTML][HTML] Neuroprotective effects of coenzyme Q10-loaded exosomes obtained from adipose-derived stem cells in a rat model of Alzheimer's disease
Alzheimer's disease (AD) is a degenerative disease that causes memory and learning
impairments as well as dementia. Coenzyme Q10 (CoQ10) is an anti-inflammatory and anti …
impairments as well as dementia. Coenzyme Q10 (CoQ10) is an anti-inflammatory and anti …
Recent advances in extracellular vesicle engineering and its applications to regenerative medicine
Extracellular vesicles (EVs) are nanosized particles that are released from cells and reflect
the characteristics of the mother cell. Recently, the EVs have been used in several types of …
the characteristics of the mother cell. Recently, the EVs have been used in several types of …