Plastids and mitochondria are the only organelles that possess genomes of endosymbiotic
origin. In recent decades, advances in sequencing technologies have contributed to a …

With the nucleus as an exception, mitochondria are the only animal cell organelles
containing their own genetic information, called mitochondrial DNA (mtDNA). During oocyte …

Mitochondria are double membrane organelles in eukaryotic cells that provide energy by
generating adenosine triphosphate (ATP) through oxidative phosphorylation. They are …

Accumulation of somatic mutations in the mitochondrial genome (mtDNA) has long been
proposed as a possible mechanism of mitochondrial and tissue dysfunction that occurs …

Mitochondria are essential for brain development. While previous studies linked
dysfunctional mitochondria with autism spectrum disorder (ASD), the role of the …

The fate of new mitochondrial and plastid mutations depends on their ability to persist and
spread among the numerous organellar genome copies within a cell (heteroplasmy). The …

Mitochondria are essential organelles with specialized functions, which play crucial roles in
energy production, calcium homeostasis, and programmed cell death. In oocytes …

Mitochondria are the main source of energy used to maintain cellular homeostasis. This
aspect of mitochondrial biology underlies their putative role in age-associated tissue …

Mutations in mitochondrial DNA (mtDNA) cause maternally inherited diseases, while
somatic mutations are linked to common diseases of aging. Although mtDNA mutations …

The mutational spectrum of the mitochondrial DNA (mtDNA) does not resemble any of the
known mutational signatures of the nuclear genome and variation in mtDNA mutational …