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Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders
Abstract In 2003 Rubenstein and Merzenich hypothesized that some forms of Autism (ASD)
might be caused by a reduction in signal-to-noise in key neural circuits, which could be the …
might be caused by a reduction in signal-to-noise in key neural circuits, which could be the …
[HTML][HTML] Sleep spindles: mechanisms and functions
Sleep spindles are burstlike signals in the electroencephalogram (EEG) of the slee**
mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As …
mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As …
Breathing coordinates cortico-hippocampal dynamics in mice during offline states
Network dynamics have been proposed as a mechanistic substrate for the information
transfer across cortical and hippocampal circuits. However, little is known about the …
transfer across cortical and hippocampal circuits. However, little is known about the …
Consciousness and sleep
Sleep is a universal, essential biological process. It is also an invaluable window on
consciousness. It tells us that consciousness can be lost but also that it can be regained, in …
consciousness. It tells us that consciousness can be lost but also that it can be regained, in …
Neuromodulation of brain state and behavior
Neural activity and behavior are both notoriously variable, with responses differing widely
between repeated presentation of identical stimuli or trials. Recent results in humans and …
between repeated presentation of identical stimuli or trials. Recent results in humans and …
Colloquium: Criticality and dynamical scaling in living systems
A celebrated and controversial hypothesis suggests that some biological systems—parts,
aspects, or groups of them—may extract important functional benefits from operating at the …
aspects, or groups of them—may extract important functional benefits from operating at the …
Psychedelics
Psychedelics (serotonergic hallucinogens) are powerful psychoactive substances that alter
perception and mood and affect numerous cognitive processes. They are generally …
perception and mood and affect numerous cognitive processes. They are generally …
Cellular mechanisms of conscious processing
Recent breakthroughs in neurobiology indicate that the time is ripe to understand how
cellular-level mechanisms are related to conscious experience. Here, we highlight the …
cellular-level mechanisms are related to conscious experience. Here, we highlight the …
[HTML][HTML] Reconstruction and simulation of neocortical microcircuitry
We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of
juvenile rat. The reconstruction uses cellular and synaptic organizing principles to …
juvenile rat. The reconstruction uses cellular and synaptic organizing principles to …
Oscillating circuitries in the slee** brain
AR Adamantidis, C Gutierrez Herrera… - Nature Reviews …, 2019 - nature.com
Brain activity during sleep is characterized by circuit-specific oscillations, including slow
waves, spindles and theta waves, which are nested in thalamocortical or hippocampal …
waves, spindles and theta waves, which are nested in thalamocortical or hippocampal …