Targeting of host organelles by pathogenic bacteria: a sophisticated subversion strategy

P Escoll, S Mondino, M Rolando… - Nature Reviews …, 2016 - nature.com
Many bacterial pathogens have evolved the ability to subvert and exploit host functions in
order to enter and replicate in eukaryotic cells. For example, bacteria have developed …

Tracking proteins secreted by bacteria: what's in the toolbox?

B Maffei, O Francetic, A Subtil - Frontiers in cellular and infection …, 2017 - frontiersin.org
Bacteria have acquired multiple systems to expose proteins on their surface, release them in
the extracellular environment or even inject them into a neighboring cell. Protein secretion …

Systematic analysis and prediction of type IV secreted effector proteins by machine learning approaches

J Wang, B Yang, Y An, T Marquez-Lago… - Briefings in …, 2019 - academic.oup.com
In the course of infecting their hosts, pathogenic bacteria secrete numerous effectors,
namely, bacterial proteins that pervert host cell biology. Many Gram-negative bacteria …

[HTML][HTML] T4SEpp: a pipeline integrating protein language models to predict bacterial type IV secreted effectors

Y Hu, Y Wang, X Hu, H Chao, S Li, Q Ni, Y Zhu… - Computational and …, 2024 - Elsevier
Many pathogenic bacteria use type IV secretion systems (T4SSs) to deliver effectors (T4SEs)
into the cytoplasm of eukaryotic cells, causing diseases. The identification of effectors is a …

T4SE-XGB: interpretable sequence-based prediction of type IV secreted effectors using eXtreme gradient boosting algorithm

T Chen, X Wang, Y Chu, Y Wang, M Jiang… - Frontiers in …, 2020 - frontiersin.org
Type IV secreted effectors (T4SEs) can be translocated into the cytosol of host cells via type
IV secretion system (T4SS) and cause diseases. However, experimental approaches to …

Stenotrophomonas maltophilia encodes a VirB/VirD4 type IV secretion system that modulates apoptosis in human cells and promotes competition against …

MY Nas, RC White, AL DuMont, AE Lopez… - Infection and …, 2019 - journals.asm.org
Stenotrophomonas maltophilia is an emerging opportunistic and nosocomial pathogen. S.
maltophilia is also a risk factor for lung exacerbations in cystic fibrosis patients. S …

T4SEfinder: a bioinformatics tool for genome-scale prediction of bacterial type IV secreted effectors using pre-trained protein language model

Y Zhang, Y Zhang, Y **ong, H Wang… - Briefings in …, 2022 - academic.oup.com
Bacterial type IV secretion systems (T4SSs) are versatile and membrane-spanning
apparatuses, which mediate both genetic exchange and delivery of effector proteins to target …

[HTML][HTML] Computational prediction of secreted proteins in gram-negative bacteria

X Hui, Z Chen, J Zhang, M Lu, X Cai, Y Deng… - Computational and …, 2021 - Elsevier
Gram-negative bacteria harness multiple protein secretion systems and secrete a large
proportion of the proteome. Proteins can be exported to periplasmic space, integrated into …

Interactions “Candidatus Liberibacter solanacearum”—Bactericera cockerelli: Haplotype Effect on Vector Fitness and Gene Expression Analyses

J Yao, P Saenkham, J Levy, F Ibanez… - Frontiers in Cellular …, 2016 - frontiersin.org
“Candidatus Liberibacter solanacearum”(Lso) has emerged as a serious threat world-wide.
Five Lso haplotypes have been identified so far. Haplotypes A and B are present in the …

[HTML][HTML] Ehrlichia's molecular tricks to manipulate their host cells

A Moumene, DF Meyer - Microbes and infection, 2016 - Elsevier
Ehrlichia is a large genus of obligate intracellular Gram-negative bacteria transmitted by
ticks that cause several emerging infectious diseases in humans and are pathogenic on …