MHC genotypes associate with resistance to a frog-killing fungus

AE Savage, KR Zamudio - Proceedings of the National …, 2011 - National Acad Sciences
The emerging amphibian disease chytridiomycosis is caused by the fungal pathogen
Batrachochytrium dendrobatidis (Bd). Amphibian populations and species differ in …

Adaptive tolerance to a pathogenic fungus drives major histocompatibility complex evolution in natural amphibian populations

AE Savage, KR Zamudio - Proceedings of the Royal …, 2016 - royalsocietypublishing.org
Amphibians have been affected globally by the disease chytridiomycosis, caused by the
fungus Batrachochytrium dendrobatidis (Bd), and we are just now beginning to understand …

Susceptibility of amphibians to chytridiomycosis is associated with MHC class II conformation

A Bataille, SD Cashins, L Grogan… - … of the Royal …, 2015 - royalsocietypublishing.org
The pathogenic chytrid fungus Batrachochytrium dendrobatidis (Bd) can cause precipitous
population declines in its amphibian hosts. Responses of individuals to infection vary greatly …

Sustained immune activation is associated with susceptibility to the amphibian chytrid fungus

AE Savage, B Gratwicke, K Hope… - Molecular …, 2020 - Wiley Online Library
The disease chytridiomycosis caused by the fungus Bd has devastated amphibian
populations worldwide. Functional genomic contributions to host susceptibility remain …

Interspecific hybridization increases MHC class II diversity in two sister species of newts

K NADACHOWSKA‐BRZYSKA, P Zieliński… - Molecular …, 2012 - Wiley Online Library
Our understanding of the evolutionary mechanisms generating variation within the highly
polymorphic major histocompatibility complex (MHC) genes remains incomplete. Assessing …

Spatiotemporal adaptive evolution of an MHC immune gene in a frog-fungus disease system

AL Trujillo, EA Hoffman, CG Becker, AE Savage - Heredity, 2021 - nature.com
Genetic diversity of major histocompatibility complex (MHC) genes is linked to reduced
pathogen susceptibility in amphibians, but few studies also examine broad spatial and …

The Amphibian Major Histocompatibility Complex—A Review and Future Outlook

J Sabino-Pinto, ME Maan - Journal of Molecular Evolution, 2025 - Springer
The major histocompatibility complex (MHC) is a cluster of functionally related genes
encoding proteins which, among other functions, mediate immune system activation. While …

Lost but not forgotten: MHC genotypes predict overwinter survival despite depauperate MHC diversity in a declining frog

AE Savage, KP Mulder, T Torres, S Wells - Conservation Genetics, 2018 - Springer
The amphibian disease chytridiomycosis, caused by the fungus Batrachochytrium
dendrobatidis (Bd), has contributed to the decline of Chiricahua leopard frogs (Rana …

Invasive bullfrogs maintain MHC polymorphism including alleles associated with chytrid fungal infection

J LaFond, KR Martin, H Dahn… - Integrative and …, 2022 - academic.oup.com
Maintenance of genetic diversity at adaptive loci may facilitate invasions by non-native
species by allowing populations to adapt to novel environments, despite the loss of diversity …

Functional variation at an expressed MHC class IIβ locus associates with Ranavirus infection intensity in larval anuran populations

AE Savage, CR Muletz-Wolz, EH Campbell Grant… - Immunogenetics, 2019 - Springer
Infectious diseases are causing catastrophic losses to global biodiversity. Iridoviruses in the
genus Ranavirus are among the leading causes of amphibian disease-related mortality …