Adaptation occurs in a variety of forms in all sensory systems, motivating the question: what
is its purpose? A productive approach has been to hypothesize that adaptation helps neural …

Adaptation is fundamental to life. All organisms adapt over timescales that span from
evolution to generations and lifetimes to moment-by-moment interactions. The nervous …

Neural systems adapt to changes in stimulus statistics. However, it is not known how stimuli
with complex temporal dynamics drive the dynamics of adaptation and the resulting firing …

There is growing evidence that the dynamics of biological systems that appear to be
exponential over short time courses are in some cases better described over the long-term …

Neurons transform time-varying inputs into action potentials emitted stochastically at a time
dependent rate. The map** from current input to output firing rate is often represented with …

Spike-frequency adaptation (SFA) is widespread in the CNS, but its function remains
unclear. In neocortical pyramidal neurons, adaptation manifests itself by an increase in the …

One of the most fundamental laws of physics is the principle of least action. Motivated by its
predictive power, we introduce a neuronal least-action principle for cortical processing of …

Single-trial analyses of ensemble activity in alert animals demonstrate that cortical circuits
dynamics evolve through temporal sequences of metastable states. Metastability has been …

The activity of ensembles of simultaneously recorded neurons can be represented as a set
of points in the space of firing rates. Even though the dimension of this space is equal to the …

Recurrently coupled networks of inhibitory neurons robustly generate oscillations in the
gamma band. Nonetheless, the corresponding Wilson-Cowan type firing rate equation for …