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Ischemia/reperfusion
T Kalogeris, CP Baines, M Krenz… - Comprehensive …, 2016 - pmc.ncbi.nlm.nih.gov
Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease,
are the most common causes of debilitating disease and death in westernized cultures. The …
are the most common causes of debilitating disease and death in westernized cultures. The …
Signal transduction through MAP kinase cascades
Publisher Summary The chapter introduces the mitogen-activated protein (MAP) kinase
(MAPK) module. The identification of MAP kinase pathways exemplifies the power of …
(MAPK) module. The identification of MAP kinase pathways exemplifies the power of …
PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
Map** of homozygous deletions on human chromosome 10q23 has led to the isolation of
a candidate tumor suppressor gene, PTEN, that appears to be mutated at considerable …
a candidate tumor suppressor gene, PTEN, that appears to be mutated at considerable …
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3, 4, 5-trisphosphate
Phosphatidylinositol 3, 4, 5-trisphosphate (PtdIns (3, 4, 5) P 3) is a key molecule involved in
cell growth signaling. We demonstrated that overexpression of PTEN, a putative tumor …
cell growth signaling. We demonstrated that overexpression of PTEN, a putative tumor …
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
D Liaw, DJ Marsh, J Li, PLM Dahia, SI Wang, Z Zheng… - Nature …, 1997 - nature.com
Cowden disease (CD) is an autosomal dominant cancer predisposition syndrome
associated with an elevated risk for tumours of the breast, thyroid and skin1–2. Lhermitte …
associated with an elevated risk for tumours of the breast, thyroid and skin1–2. Lhermitte …
Synthesis and function of 3-phosphorylated inositol lipids
▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …
Regulation of the Arabidopsis transcriptome by oxidative stress
Oxidative stress, resulting from an imbalance in the accumulation and removal of reactive
oxygen species such as hydrogen peroxide (H2O2), is a challenge faced by all aerobic …
oxygen species such as hydrogen peroxide (H2O2), is a challenge faced by all aerobic …
The molecular basis for oxidative stress-induced insulin resistance
Reactive oxygen and nitrogen molecules have been typically viewed as the toxic by-
products of metabolism. However, accumulating evidence has revealed that reactive …
products of metabolism. However, accumulating evidence has revealed that reactive …
[HTML][HTML] Glutathione and glutaredoxin in redox regulation and cell signaling of the lens
MF Lou - Antioxidants, 2022 - mdpi.com
The ocular lens has a very high content of the antioxidant glutathione (GSH) and the
enzymes that can recycle its oxidized form, glutathione disulfide (GSSG), for further use. It …
enzymes that can recycle its oxidized form, glutathione disulfide (GSSG), for further use. It …
AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation
▪ Abstract The protein kinase Akt/PKB is activated via a multistep process by a variety of
signals. In the early steps of this process, PI-3 kinase-generated D3-phosphorylated …
signals. In the early steps of this process, PI-3 kinase-generated D3-phosphorylated …