A review on diverse heterocyclic compounds as the privileged scaffolds in antimalarial drug discovery

PN Kalaria, SC Karad, DK Raval - European journal of medicinal chemistry, 2018 - Elsevier
The upward extend of malaria collectively with the emergence of resistance against
predictable drugs has put enormous pressure on public health systems to introduce new …

1, 3, 5‐Triazine: A versatile pharmacophore with diverse biological activities

S Singh, MK Mandal, A Masih, A Saha… - Archiv der …, 2021 - Wiley Online Library
Triazine and its derivatives have been the epicenter of chemotherapeutic molecules due to
their effective biological activities, such as antibacterial, fungicidal, antimalarial, anticancer …

“Recycling” classical drugs for malaria

C Teixeira, N Vale, B Perez, A Gomes… - Chemical …, 2014 - ACS Publications
Malaria has been a human health concern ever since the dawn of mankind, but despite the
huge struggles made to date to fight this infection, in 2012 over half a million people were …

Functionalized triazines and tetrazines: Synthesis and applications

J Mondal, A Sivaramakrishna - Topics in Current Chemistry, 2022 - Springer
The molecules possessing triazine and tetrazine moieties belong to a special class of
heterocyclic compounds. Both triazines and tetrazines are building blocks and have …

Design and discovery of novel monastrol-1,3,5-triazines as potent anti-breast cancer agent via attenuating Epidermal Growth Factor Receptor tyrosine kinase

JK Srivastava, GG Pillai, HR Bhat, A Verma… - Scientific Reports, 2017 - nature.com
A novel series of hybrid analogues of monastrol-1, 3, 5-triazine were designed and
developed via one-pot synthesis using Bi (NO3) 3 as a catalyst. Entire compounds were …

Quinine conjugates and quinine analogues as potential antimalarial agents

RA Jones, SS Panda, CD Hall - European journal of medicinal chemistry, 2015 - Elsevier
Malaria is a tropical disease, prevalent in Southeast Asia and Africa, resulting in over half a
million deaths annually; efforts to develop new antimalarial agents are therefore particularly …

Hybrid molecules with potential in vitro antiplasmodial and in vivo antimalarial activity against drug‐resistant Plasmodium falciparum

LS Feng, Z Xu, L Chang, C Li, XF Yan… - Medicinal Research …, 2020 - Wiley Online Library
Malaria is a tropical disease, leading to around half a million deaths annually. Antimalarials
such as quinolines are crucial to fight against malaria, but malaria control is extremely …

Privileged S-Triazines: Structure and Pharmacological Applications

DR Shah, RP Modh, KH Chikhalia - Future medicinal chemistry, 2014 - Taylor & Francis
This review summarizes recent reports on s-triazine and its respective analogs from the
medicinal chemistry angle. Due to its high reactivity and binding characteristic towards …

Design, synthesis, anticancer, antibacterial, and antifungal evaluation of 4‐aminoquinoline‐1, 3, 5‐triazine derivatives

HR Bhat, A Masih, A Shakya… - Journal of …, 2020 - Wiley Online Library
Abstract A series of 4‐aminoquinoline 1, 3, 5‐triazine derivatives were synthesized and
evaluated for anticancer activity against cancer cell lines HeLa, MCF‐7, HL‐60, HepG2 …

A review of antimalarial activity of two or three nitrogen atoms containing heterocyclic compounds

A Chugh, A Kumar, A Verma, S Kumar… - Medicinal Chemistry …, 2020 - Springer
Malaria, a nocuous disease, which has become a major challenge for the health resulting in
deaths of millions of people around the globe. Malaria is a parasitic disease propagated by …