Tutorial: a guide to performing polygenic risk score analyses

SW Choi, TSH Mak, PF O'Reilly - Nature protocols, 2020 - nature.com
A polygenic score (PGS) or polygenic risk score (PRS) is an estimate of an individual's
genetic liability to a trait or disease, calculated according to their genotype profile and …

The new genetics of intelligence

R Plomin, S Von Stumm - Nature Reviews Genetics, 2018 - nature.com
Intelligence—the ability to learn, reason and solve problems—is at the forefront of
behavioural genetic research. Intelligence is highly heritable and predicts important …

PRSice-2: Polygenic Risk Score software for biobank-scale data

SW Choi, PF O'Reilly - Gigascience, 2019 - academic.oup.com
Background Polygenic risk score (PRS) analyses have become an integral part of
biomedical research, exploited to gain insights into shared aetiology among traits, to control …

Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

S Sniekers, S Stringer, K Watanabe, PR Jansen… - Nature …, 2017 - nature.com
Intelligence is associated with important economic and health-related life outcomes 1.
Despite intelligence having substantial heritability 2 (0.54) and a confirmed polygenic …

[HTML][HTML] Comparing within-and between-family polygenic score prediction

S Selzam, SJ Ritchie, JB **ault, CA Reynolds… - The American Journal of …, 2019 - cell.com
Polygenic scores are a popular tool for prediction of complex traits. However, prediction
estimates in samples of unrelated participants can include effects of population stratification …

[КНИГА][B] Concepts and theories of human development

RM Lerner - 2018 - taylorfrancis.com
Concepts and Theories of Human Development is the most comprehensive and in-depth
overview of the foundational theoretical contributions to understanding human development …

Multi-polygenic score approach to trait prediction

E Krapohl, H Patel, S Newhouse, CJ Curtis… - Molecular …, 2018 - nature.com
A primary goal of polygenic scores, which aggregate the effects of thousands of trait-
associated DNA variants discovered in genome-wide association studies (GWASs), is to …

A polygenic p factor for major psychiatric disorders

S Selzam, JRI Coleman, A Caspi, TE Moffitt… - Translational …, 2018 - nature.com
It has recently been proposed that a single dimension, called the p factor, can capture a
person's liability to mental disorder. Relevant to the p hypothesis, recent genetic research …

Twins early development study: A genetically sensitive investigation into behavioral and cognitive development from infancy to emerging adulthood

K Rimfeld, M Malanchini, T Spargo… - Twin Research and …, 2019 - cambridge.org
The Twins Early Development Study (TEDS) is a longitudinal twin study that recruited over
16,000 twin-pairs born between 1994 and 1996 in England and Wales through national birth …

New literacy challenge for the twenty-first century: genetic knowledge is poor even among well educated

R Chapman, M Likhanov, F Selita, I Zakharov… - Journal of community …, 2019 - Springer
We live in an age of rapidly advancing genetic research. This research is generating new
knowledge that has implications for personal health and well-being. The present study …