Behavioral control by depolarized and hyperpolarized states of an integrating neuron

A Sordillo, CI Bargmann - Elife, 2021 - elifesciences.org
Coordinated transitions between mutually exclusive motor states are central to behavioral
decisions. During locomotion, the nematode Caenorhabditis elegans spontaneously cycles …

Hierarchical behavior control by a single class of interneurons

J Huo, T Xu, Q Liu, M Polat, S Kumar, X Zhang… - Proceedings of the …, 2024 - pnas.org
Animal behavior is organized into nested temporal patterns that span multiple timescales.
This behavior hierarchy is believed to arise from a hierarchical neural architecture: Neurons …

Inhibitory feedback from the motor circuit gates mechanosensory processing in Caenorhabditis elegans

S Kumar, AK Sharma, A Tran, M Liu, AM Leifer - PLoS biology, 2023 - journals.plos.org
Animals must integrate sensory cues with their current behavioral context to generate a
suitable response. How this integration occurs is poorly understood. Previously, we …

Integration of spatially opposing cues by a single interneuron guides decision-making in C. elegans

A Gat, V Pechuk, S Peedikayil-Kurien, S Karimi… - Cell Reports, 2023 - cell.com
The capacity of animals to respond to hazardous stimuli in their surroundings is crucial for
their survival. In mammals, complex evaluations of the environment require large numbers …

[HTML][HTML] Behavioral adjustment of C. elegans to mechanosensory loss requires intact mechanosensory neurons

M Staum, AC Abraham, R Arbid, VS Birari… - Plos …, 2024 - journals.plos.org
Sensory neurons specialize in detecting and signaling the presence of diverse
environmental stimuli. Neuronal injury or disease may undermine such signaling …

pOpsicle: An all-optical reporter system for synaptic vesicle recycling combining pH-sensitive fluorescent proteins with optogenetic manipulation of neuronal activity

M Seidenthal, B Jánosi, N Rosenkranz… - Frontiers in Cellular …, 2023 - frontiersin.org
pH-sensitive fluorescent proteins are widely used to study synaptic vesicle (SV) fusion and
recycling. When targeted to the lumen of SVs, fluorescence of these proteins is quenched by …

Nervous system guides behavioral immunity in Caenorhabditis elegans

Y Wang, X Sun, L Feng, K Zhang, W Yang - PeerJ, 2024 - peerj.com
Caenorhabditis elegans is a versatile model organism for exploring complex biological
systems. Microbes and the external environment can affect the nervous system and drive …

Olfactory combinatorial coding supports risk-reward decision making in C. elegans

MZH Saad, WG Ryan, CA Edwards, BN Szymanski… - bioRxiv, 2024 - biorxiv.org
Vertebrate and insect olfactory systems generate diversity in odor perception using
combinatorial coding, where individual odorant molecules activate unique but overlap** …

Coordinated electrical and chemical signaling between two neurons orchestrates switching of motor states

M Bach, A Bergs, B Mulcahy, M Zhen, A Gottschalk - bioRxiv, 2023 - biorxiv.org
To survive in a complex environment, animals must respond to external cues, eg, to escape
threats or to navigate towards favorable locations. Navigating requires transition between …

pOpsicle: An all-optical reporter system for synaptic vesicle recycling combining pH-sensitive fluorescent proteins with optogenetic manipulation of neuronal activity

M Seidenthal, B Jánosi, N Rosenkranz, N Schuh… - bioRxiv, 2022 - biorxiv.org
Abstract pH-sensitive fluorescent proteins are widely used to study synaptic vesicle (SV)
fusion and recycling. When targeted to the lumen of SVs, fluorescence of these proteins is …