Epidemiological studies established that elevated homocysteine, an important intermediate
in folate, vitamin B12, and one carbon metabolism, is associated with poor health, including …

Posttranslational modification of a protein, either alone or in combination with other
modifications, can control properties of that protein, such as enzymatic activity, localization …

The AMP-forming acetyl-CoA synthetase is regulated by lysine acetylation both in bacteria
and eukaryotes. However, the underlying mechanism is poorly understood. The Bacillus …

Sirtuins are deacetylase enzymes widely distributed in all domains of life. Although for
decades they have been related only to histones deacetylation in eukaryotic organisms …

Ac (et) ylation is a post-translational modification present in all domains of life. First identified
in mammals in histones to regulate RNA synthesis, today it is known that is regulates …

Our previous studies have profiled lysine acetylation and succinylation modifications in
Aeromonas hydrophila protein and have found that CobB may be involved in lysine …

Lipoic acid is an essential metabolic cofactor added as a posttranslational modification on
several multimeric enzyme complexes. These protein complexes, evolutionarily conserved …

Homocysteine thiolactone (HTL), a toxic metabolite of homocysteine (Hcy) in
hyperhomocysteinemia (HHcy), is known to modify protein structure and function, leading to …

Lysine acetylation, either by lysine acetyltransferase (KAT) enzymes or nonenzymatic
(chemical) acetyl donors such as acetyl phosphate (AcP), is a common post-translational …

Lipoylation is a rare, but highly conserved lysine posttranslational modification. To date, it is
known to occur on only four multimeric metabolic enzymes in mammals, yet these proteins …