Based upon evidence that the therapeutic properties of C annabis preparations are not
solely dependent upon the presence of Δ9‐tetrahydrocannabinol (THC), pharmacological …

The endocannabinoid system (ECS) is composed of two G protein-coupled receptors
(GPCRs), the cannabinoid CB1 and CB2 receptors, and the two main endogenous lipid …

Cannabis has been used for centuries to treat seizures. Recent anecdotal reports,
accumulating animal model data, and mechanistic insights have raised interest in cannabis …

Background The use of cannabis, or marijuana, for medicinal purposes is deeply rooted
though history, dating back to ancient times. It once held a prominent position in the history …

The isolation and identification of the discrete plant cannabinoids in marijuana revived
interest in analyzing historical therapeutic claims made for cannabis in clinical case studies …

Cannabis has been used to treat convulsions and other disorders since ancient times. In the
last few decades, preclinical animal studies and clinical investigations have established the …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Endocannabinoid signaling is a key regulator of synaptic neurotransmission throughout the
brain. Compelling evidence shows that its perturbation leads to development of epileptic …

Endocannabinoids are lipid-derived messengers, and both their synthesis and breakdown
are under tight spatiotemporal regulation. As retrograde signalling molecules …

The endocannabinoid (eCB) signaling system plays a key role in short-term and long-term
synaptic plasticity in brain regions involved in various neural functions ranging from action …