Ageing is a complex, multifaceted process leading to widespread functional decline that
affects every organ and tissue, but it remains unknown whether ageing has a unifying causal …

Mitochondrial DNA copy number (mtDNA-CN) is a biomarker of mitochondrial function and
levels of mtDNA-CN have been reproducibly associated with overall mortality and a number …

There is growing scientific interest to develop scalable biological measures that capture
mitochondrial (dys) function. Mitochondria have their own genome, the mitochondrial DNA …

Quantifying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in clinical
samples is crucial for early diagnosis and timely medical treatment of coronavirus disease …

Skeletal muscle aging is associated with a significant loss of skeletal muscle strength and
power (ie, dynapenia), muscle mass and quality of life, a phenomenon known as …

Background Systemic low-grade inflammation observed in diet-induced obesity has been
associated with dysbiosis and disturbance of intestinal homeostasis. This latter relies on an …

The PCR technique has been known to the general public since the pandemic outbreak of
COVID-19. This technique has progressed through three stages: from simple PCR to real …

Mitochondria are the “gatekeeper” in a wide range of cellular functions, signaling events, cell
homeostasis, proliferation, and apoptosis. Consequently, mitochondrial injury is linked to …

Primary mitochondrial disease describes a diverse group of neuro-metabolic disorders
characterised by impaired oxidative phosphorylation. Diagnosis is challenging;> 350 genes …

One of the major mechanisms of drug-induced liver injury includes mitochondrial
perturbation and dysfunction. This is not a surprise, given that mitochondria are essential …