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The Role of TCF7L2 in Type 2 Diabetes
TCF7L2 is the most potent locus for type 2 diabetes (T2D) risk and the first locus to have
been robustly reported by genomic linkage studies. TCF7L2 is a transcription factor that …
been robustly reported by genomic linkage studies. TCF7L2 is a transcription factor that …
Enhancers: five essential questions
Although enhancers are crucial and widespread gene-regulatory elements, we are far from
a complete understanding of how they function or their importance in areas such as disease …
a complete understanding of how they function or their importance in areas such as disease …
Efficient integrative multi-SNP association analysis via deterministic approximation of posteriors
With the increasing availability of functional genomic data, incorporating genomic
annotations into genetic association analysis has become a standard procedure. However …
annotations into genetic association analysis has become a standard procedure. However …
The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing β-Cell Function and Hepatic …
OBJECTIVE In this study, we aimed to explore the mechanism by which TCF7L2 rs7903146
risk allele confers susceptibility to impaired glucose tolerance (IGT) or type 2 diabetes (T2D) …
risk allele confers susceptibility to impaired glucose tolerance (IGT) or type 2 diabetes (T2D) …
[HTML][HTML] BRCA1 and its network of interacting partners
CM Christou, K Kyriacou - Biology, 2012 - mdpi.com
BRCA1 is a large multi-domain protein with a pivotal role in maintaining genome stability
and cell cycle progression. Germline mutations in the BRCA1 gene confer an estimated …
and cell cycle progression. Germline mutations in the BRCA1 gene confer an estimated …
How does the Mediterranean diet promote cardiovascular health? Current progress toward molecular mechanisms: Gene‐diet interactions at the genomic …
Epidemiological evidence supports a health‐promoting effect of the Mediterranean Diet
(MedDiet), especially in the prevention of cardiovascular diseases. These cardiovascular …
(MedDiet), especially in the prevention of cardiovascular diseases. These cardiovascular …
TCF7L2 and glucose metabolism: time to look beyond the pancreas
MA Nobrega - Diabetes, 2013 - pmc.ncbi.nlm.nih.gov
Noncoding genetic variation in the locus encod-ing for the Wnt signaling effector TCF7L2
remains the strongest genetic determinant of type 2 diabetes (T2D) risk in humans. This …
remains the strongest genetic determinant of type 2 diabetes (T2D) risk in humans. This …
Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in mice
Non-coding variation within TCF7L2 remains the strongest genetic determinant of type 2
diabetes risk in humans. A considerable effort has been placed in understanding the …
diabetes risk in humans. A considerable effort has been placed in understanding the …
Admixture map** and fine-map** of type 2 diabetes susceptibility loci in African American women
African American women are disproportionately affected by type 2 diabetes. Genetic factors
may explain part of the excess risk. More than 100 genetic variants have been associated …
may explain part of the excess risk. More than 100 genetic variants have been associated …
Characterization of the transcriptional machinery bound across the widely presumed type 2 diabetes causal variant, rs7903146, within TCF7L2
Q **a, S Deliard, CX Yuan, ME Johnson… - European Journal of …, 2015 - nature.com
Resolving the underlying functional mechanism to a given genetic association has proven
extremely challenging. However, the strongest associated type 2 diabetes (T2D) locus …
extremely challenging. However, the strongest associated type 2 diabetes (T2D) locus …