Over the last 20 years, there has been increasing focus on the development of novel stem
cell based therapies for the treatment of disorders and diseases affecting the enteric nervous …

Intestinal epithelial cells (IECs) are crucial for the digestive process and nutrient absorption.
The intestinal epithelium is composed of the different cell types of the small intestine (mainly …

BACKGROUND & AIMS: Altered gastrointestinal motility is associated with significant
morbidity and health care costs. Toll-like receptors (TLR) regulate intestinal homeostasis …

Background Gastrointestinal dysfunction is very common in diabetic patients. We assessed
the changes in the colonic enteric nervous system using colectomy specimens and intestinal …

Cell therapy has the potential to treat gastrointestinal motility disorders caused by diseases
of the enteric nervous system. Many studies have demonstrated that various stem/progenitor …

Enteric neuronal degeneration, as seen in inflammatory bowel disease, obesity, and
diabetes, can lead to gastrointestinal dysmotility. Pyroptosis is a novel form of programmed …

Spinal cord injury (SCI) is a serious condition with limited treatment options. Neural
progenitor cell (NPC) transplantation is a promising treatment option, and the identification …

Background & Aims High-fat diet (HFD) feeding is associated with gastrointestinal motility
disorders. We recently reported delayed colonic motility in mice fed a HFD for 11 weeks. In …

Key points A high‐fat diet (60% kcal from fat) is associated with motility disorders inducing
constipation and loss of nitrergic myenteric neurons in the proximal colon. Gut microbiota …

The endothelin system is a vertebrate-specific innovation with important roles in regulating
the cardiovascular system and renal and pulmonary processes, as well as the development …