The importance and role of the estrogen receptor (ER) pathway has been well-documented
in both breast cancer (BC) development and progression. The treatment of choice in women …

Spleen tyrosine kinase (Syk) is a cytoplasmic protein tyrosine kinase well known for its
ability to couple immune cell receptors to intracellular signaling pathways that regulate …

SYK (spleen tyrosine kinase) is well-characterized in the immune system as an essential
enzyme required for signaling through multiple classes of immune recognition receptors. As …

The ability to obtain in-depth understanding of signaling networks in cells is a key objective
of systems biology research. Such ability depends largely on unbiased and reproducible …

Most human genes produce multiple mRNA isoforms through alternative splicing. However,
the biological relevance of most splice variants remains unclear. In this study, we evaluated …

The spleen tyrosine kinase Syk was long thought to be a hematopoietic cell-specific
signaling molecule. Recent evidence demonstrated that it is also expressed by many non …

In this study, we have addressed how Lyn kinase signaling mediates nilotinib-resistance by
quantitative phospho-proteomics using Stable Isotope Labeling with Amino acid in Cell …

The nonreceptor protein spleen tyrosine kinase (Syk) is a key mediator of signal
transduction in a variety of cell types, including B lymphocytes. We show that deregulated …

Purpose: The aim of present study was to investigate the methylation and expression status
of spleen tyrosine kinase (SYK) in human hepatocellular carcinoma (HCC) and to evaluate …

Spleen tyrosine kinase (SYK) has predominantly been studied in hematopoietic cells, where
it is involved in immunoreceptor-mediated signaling. However, SYK expression has been …