An altered pattern of epigenetic modifications is central to many common human diseases,
including cancer. Many studies have explored the mosaic patterns of DNA methylation and …

Epigenetic changes can be defined as stable molecular alterations of a cellular phenotype
such as the gene expression profile of a cell that are heritable during somatic cell divisions …

Purpose: Even though urothelial cancer is the fourth most common tumor type among males,
progress in treatment has been scarce. A problem in day-to-day clinical practice is that …

A three-dimensional chromatin state underpins the structural and functional basis of the
genome by bringing regulatory elements and genes into close spatial proximity to ensure …

Immunotherapies targeting the PD-1/PD-L1 axis are now a mainstay in the clinical
management of multiple cancer types, however, many tumors still fail to respond. CCL2 is …

Because of their somatic cell origin, human induced pluripotent stem cells (HiPSCs) are
assumed to carry a normal diploid genome, and adaptive chromosomal aberrations have …

Muscle-invasive bladder carcinoma (MIBC) constitutes a heterogeneous group of tumors
with a poor outcome. Molecular stratification of MIBC may identify clinically relevant tumor …

Current clinical judgment in bladder cancer (BC) relies primarily on pathological stage and
grade. We investigated whether a molecular classification of tumor cell differentiation, based …

Background IGF2BP3 functions as an RNA-binding protein (RBP) and plays a role in the
posttranscriptional control of mRNA localization, stability, and translation. Its dysregulation is …

In the present investigation, we sought to refine the classification of urothelial carcinoma by
combining information on gene expression, genomic, and gene mutation levels. For these …