Doxorubicin—an agent with multiple mechanisms of anticancer activity

M Kciuk, A Gielecińska, S Mujwar, D Kołat… - Cells, 2023 - mdpi.com
Doxorubicin (DOX) constitutes the major constituent of anti-cancer treatment regimens
currently in clinical use. However, the precise mechanisms of DOX's action are not fully …

The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy

HH Han, HM Wang, P Jangili, M Li, L Wu… - Chemical Society …, 2023 - pubs.rsc.org
Cancer remains as one of the most significant health problems, with approximately 19
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …

Advances in our understanding of the molecular mechanisms of action of cisplatin in cancer therapy

PB Tchounwou, S Dasari, FK Noubissi… - Journal of …, 2021 - Taylor & Francis
Cisplatin and other platinum-based chemotherapeutic drugs have been used extensively for
the treatment of human cancers such as bladder, blood, breast, cervical, esophageal, head …

Nanocomposites based on lanthanide-doped upconversion nanoparticles: diverse designs and applications

K Du, J Feng, X Gao, H Zhang - Light: Science & Applications, 2022 - nature.com
Lanthanide-doped upconversion nanoparticles (UCNPs) have aroused extraordinary
interest due to the unique physical and chemical properties. Combining UCNPs with other …

Oxidative stress injury in doxorubicin-induced cardiotoxicity

M Songbo, H Lang, C **nyong, X Bin, Z **, S Liang - Toxicology letters, 2019 - Elsevier
Doxorubicin (DOX) is widely used as a broad-spectrum anti-tumor anthracycline to treat
various cancers. The serious adverse effects of DOX on cardiotoxicity limit its clinical …

DNA nanotechnology-enabled drug delivery systems

Q Hu, H Li, L Wang, H Gu, C Fan - Chemical reviews, 2018 - ACS Publications
Over the past decade, we have seen rapid advances in applying nanotechnology in
biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging …

FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT

X Zhang, C Hu, CY Kong, P Song, HM Wu… - Cell Death & …, 2020 - nature.com
Oxidative stress and cardiomyocyte apoptosis play critical roles in doxorubicin (DOX)-
induced cardiotoxicity. Previous studies indicated that fibronectin type III domain-containing …

[HTML][HTML] Doxorubicin-based hybrid compounds as potential anticancer agents: a review

S Peter, S Alven, RB Maseko, BA Aderibigbe - Molecules, 2022 - mdpi.com
The scarcity of novel and effective therapeutics for the treatment of cancer is a pressing and
alarming issue that needs to be prioritized. The number of cancer cases and deaths are …

Advances in aptamer-mediated targeted delivery system for cancer treatment

S He, Y Du, H Tao, H Duan - International journal of biological …, 2023 - Elsevier
Aptamers with high affinity and specificity for certain targets have rapidly become a novel
class of targeted ligands applicated in drug delivery. Based on the excellent characteristics …

Multi‐functional liposome: a powerful theranostic nano‐platform enhancing photodynamic therapy

X Cheng, J Gao, Y Ding, Y Lu, Q Wei, D Cui… - Advanced …, 2021 - Wiley Online Library
Although photodynamic therapy (PDT) has promising advantages in almost non‐invasion,
low drug resistance, and low dark toxicity, it still suffers from limitations in the lipophilic …