Chalcone: a promising bioactive scaffold in medicinal chemistry
Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …
Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer
The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …
urgent due to the development of malignancies that are resistant to chemotherapeutic …
The role of phenolic compounds in the fight against cancer–a review
Cancer is a worldwide scourge; it's the leading cause of death in developed countries and is
increasing in develo** countries. Mankind has been trying with effort to find better and …
increasing in develo** countries. Mankind has been trying with effort to find better and …
Design, in silico studies and biological evaluation of novel chalcones tethered triazolo[3,4-a]isoquinoline as EGFR inhibitors targeting resistance in non-small cell …
A novel series of six [1, 2, 4] triazolo [3, 4-a] isoquinolin-3-yl)-3-(1, 3-diphenyl-1 H-pyrazol-4-
yl) prop-2-en-1-ones (3a–3f) was designed and synthesized. They were characterized …
yl) prop-2-en-1-ones (3a–3f) was designed and synthesized. They were characterized …
Novel 3-(pyrazol-4-yl)-2-(1H-indole-3-carbonyl)acrylonitrile derivatives induce intrinsic and extrinsic apoptotic death mediated P53 in HCT116 colon carcinoma
A novel series of α-cyano indolylchalcones was prepared, and their chemical structures
were confirmed based on the different spectral data. Among them, compound 7f was …
were confirmed based on the different spectral data. Among them, compound 7f was …
Anticancer activity of novel 3‐(furan‐2‐yl) pyrazolyl and 3‐(thiophen‐2‐yl) pyrazolyl hybrid chalcones: Synthesis and in vitro studies
MT Helmy, FM Sroor, KF Mahrous… - Archiv der …, 2022 - Wiley Online Library
Twelve novel chalcone derivatives were prepared using the Claisen–Schmidt condensation
reaction. The reaction of 4‐acetyl‐5‐furan/thiophene‐pyrazole derivatives 5 with the …
reaction. The reaction of 4‐acetyl‐5‐furan/thiophene‐pyrazole derivatives 5 with the …
Novel Tetrahydro-[1,2,4]triazolo[3,4-a]isoquinoline Chalcones Suppress Breast Carcinoma through Cell Cycle Arrests and Apoptosis
Chalcones are interesting anticancer drug candidates which have attracted much interest
due to their unique structure and their extensive biological activity. Various functional …
due to their unique structure and their extensive biological activity. Various functional …
Synthesis, cytotoxicity, anti-inflammatory, anti-metastatic and anti-oxidant activities of novel chalcones incorporating 2-phenoxy-N-arylacetamide and thiophene …
Eight Novel chalcones were synthesized and their structures were confirmed by different
spectral tools. All the prepared compounds were subjected to SRB cytotoxic screening …
spectral tools. All the prepared compounds were subjected to SRB cytotoxic screening …
Molecular docking study, cytotoxicity, cell cycle arrest and apoptotic induction of novel chalcones incorporating thiadiazolyl isoquinoline in cervical cancer
Background: Chalcones are naturally occurring compounds found in various plant species
which are widely used for the traditional popular treatments. Chalcones are distinguished …
which are widely used for the traditional popular treatments. Chalcones are distinguished …
Synthesis, anticancer and radiosensitizing evaluation of some novel sulfonamide derivatives
MM Ghorab, FA Ragab, HI Heiba, MG El-Gazzar… - European journal of …, 2015 - Elsevier
In this study, novel series of sulfonamide derivatives were synthesized starting from 2-
cyanoacetyl) hydrazono) ethyl) phenyl) benzenesulfonamide 4a and 2-cyanoacetyl) …
cyanoacetyl) hydrazono) ethyl) phenyl) benzenesulfonamide 4a and 2-cyanoacetyl) …