Genetic models of human and mouse dendritic cell development and function
Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have
numerous shared characteristics between mice and humans. Human counterparts of mouse …
numerous shared characteristics between mice and humans. Human counterparts of mouse …
Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function
Respiratory disease is the third leading cause of death in the industrialized world.
Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of …
Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of …
Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity
Recent studies in both mice and humans have suggested that gut microbiota could
modulate tumor responsiveness to chemo-or immunotherapies. However, the underlying …
modulate tumor responsiveness to chemo-or immunotherapies. However, the underlying …
Innovations present in the primate interneuron repertoire
Primates and rodents, which descended from a common ancestor around 90 million years
ago, exhibit profound differences in behaviour and cognitive capacity; the cellular basis for …
ago, exhibit profound differences in behaviour and cognitive capacity; the cellular basis for …
Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages
CSN Klose, M Flach, L Möhle, L Rogell, T Hoyler… - Cell, 2014 - cell.com
Innate lymphoid cells (ILCs) are a recently recognized group of lymphocytes that have
important functions in protecting epithelial barriers against infections and in maintaining …
important functions in protecting epithelial barriers against infections and in maintaining …
Active eosinophils regulate host defence and immune responses in colitis
In the past decade, single-cell transcriptomics has helped to uncover new cell types and
states and led to the construction of a cellular compendium of health and disease. Despite …
states and led to the construction of a cellular compendium of health and disease. Despite …
Regenerative lineages and immune-mediated pruning in lung cancer metastasis
Developmental processes underlying normal tissue regeneration have been implicated in
cancer, but the degree of their enactment during tumor progression and under the selective …
cancer, but the degree of their enactment during tumor progression and under the selective …
In vitro generation of human pluripotent stem cell derived lung organoids
BR Dye, DR Hill, MAH Ferguson, YH Tsai, MS Nagy… - elife, 2015 - elifesciences.org
Recent breakthroughs in 3-dimensional (3D) organoid cultures for many organ systems
have led to new physiologically complex in vitro models to study human development and …
have led to new physiologically complex in vitro models to study human development and …
The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation
The type 2 cytokines interleukin (IL)-4, IL-5, IL-9 and IL-13 have important roles in
stimulating innate and adaptive immune responses that are required for resistance to …
stimulating innate and adaptive immune responses that are required for resistance to …
Generation of lung organoids from human pluripotent stem cells in vitro
The lung epithelium is derived from the endodermal germ layer, which undergoes a complex
series of endoderm–mesoderm-mediated signaling events to generate the final arborized …
series of endoderm–mesoderm-mediated signaling events to generate the final arborized …