Spin hyperpolarization in modern magnetic resonance

J Eills, D Budker, S Cavagnero, EY Chekmenev… - Chemical …, 2023 - ACS Publications
Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …

Hyperpolarized NMR Spectroscopy: d‐DNP, PHIP, and SABRE Techniques

KV Kovtunov, EV Pokochueva… - Chemistry–An Asian …, 2018 - Wiley Online Library
The intensity of NMR signals can be enhanced by several orders of magnitude by using
various techniques for the hyperpolarization of different molecules. Such approaches can …

Sensitivity enhancement in solution NMR: Emerging ideas and new frontiers

JH Lee, Y Okuno, S Cavagnero - Journal of magnetic resonance, 2014 - Elsevier
Modern NMR spectroscopy has reached an unprecedented level of sophistication in the
determination of biomolecular structure and dynamics at atomic resolution in liquids …

Nitrogen-15 dynamic nuclear polarization of nicotinamide derivatives in biocompatible solutions

JP Peters, A Brahms, V Janicaud, M Anikeeva… - Science …, 2023 - science.org
Dissolution dynamic nuclear polarization (dDNP) increases the sensitivity of magnetic
resonance imaging by more than 10,000 times, enabling in vivo metabolic imaging to be …

Practical dissolution dynamic nuclear polarization

SJ Elliott, Q Stern, M Ceillier, T El Daraï… - Progress in Nuclear …, 2021 - Elsevier
This review article intends to provide insightful advice for dissolution-dynamic nuclear
polarization in the form of a practical handbook. The goal is to aid research groups to …

Brute-force hyperpolarization for NMR and MRI

ML Hirsch, N Kalechofsky, A Belzer… - Journal of the …, 2015 - ACS Publications
Hyperpolarization (HP) of nuclear spins is critical for ultrasensitive nuclear magnetic
resonance (NMR) and magnetic resonance imaging (MRI). We demonstrate an approach …

Transportable hyperpolarized metabolites

X Ji, A Bornet, B Vuichoud, J Milani, D Gajan… - Nature …, 2017 - nature.com
Nuclear spin hyperpolarization of 13C-labelled metabolites by dissolution dynamic nuclear
polarization can enhance the NMR signals of metabolites by several orders of magnitude …

Boosting dissolution dynamic nuclear polarization by cross polarization

A Bornet, R Melzi, AJ Perez Linde… - The journal of …, 2013 - ACS Publications
The efficiency of dissolution dynamic nuclear polarization can be boosted by Hartmann–
Hahn cross polarization at temperatures near 1.2 K. This enables high throughput of …

Porous functionalized polymers enable generating and transporting hyperpolarized mixtures of metabolites

T El Daraï, SF Cousin, Q Stern, M Ceillier… - Nature …, 2021 - nature.com
Hyperpolarization by dissolution dynamic nuclear polarization (dDNP) has enabled
promising applications in spectroscopy and imaging, but remains poorly widespread due to …

High field dynamic nuclear polarization at 6.7 T: Carbon-13 polarization above 70% within 20 min

S Jannin, A Bornet, R Melzi, G Bodenhausen - Chemical Physics Letters, 2012 - Elsevier
In most applications of dissolution-DNP, the polarization of nuclei with low gyromagnetic
ratios such as 13C is enhanced directly by irradiating the ESR transitions of radicals with …