Immunological decision‐making: how does the immune system decide to mount a helper T‐cell response?
Aberrant T‐cell responses underpin a range of diseases, including asthma and allergy and
autoimmune diseases. Pivotal immune elements of these diseases are the development of …
autoimmune diseases. Pivotal immune elements of these diseases are the development of …
Nuclear hormone receptors enable macrophages and dendritic cells to sense their lipid environment and shape their immune response
A key issue in the immune system is to generate specific cell types, often with opposing
activities. The mechanisms of differentiation and subtype specification of immune cells such …
activities. The mechanisms of differentiation and subtype specification of immune cells such …
[HTML][HTML] A survey on the role of interleukin-10 in breast cancer: A narrative
E Sheikhpour, P Noorbakhsh, E Foroughi… - … of biochemistry & …, 2018 - ncbi.nlm.nih.gov
Background: Interleukin (IL)-10, a multifunctional immune-regulatory cytokine with both
immunosuppressive and anti-angiogenic functions, is produced by immune cells including …
immunosuppressive and anti-angiogenic functions, is produced by immune cells including …
Role of interleukin-10 in breast cancer
Cytokines are low molecular weight regulatory proteins or glycoprotein that modulates the
intensity and duration of immune response by stimulating or inhibiting the activation …
intensity and duration of immune response by stimulating or inhibiting the activation …
Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance
FW Kiefer, M Zeyda, K Gollinger, B Pfau, A Neuhofer… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE Obesity is associated with a state of chronic low-grade inflammation mediated
by immune cells that are primarily located to adipose tissue and liver. The chronic …
by immune cells that are primarily located to adipose tissue and liver. The chronic …
Dehydroepiandrosterone inhibits the Src/STAT3 constitutive activation in pulmonary arterial hypertension
R Paulin, J Meloche, MH Jacob… - American Journal …, 2011 - journals.physiology.org
Pulmonary arterial hypertension (PAH) is an obstructive vasculopathy characterized by
enhanced pulmonary artery smooth muscle cell (PASMC) proliferation and suppressed …
enhanced pulmonary artery smooth muscle cell (PASMC) proliferation and suppressed …
Understanding the molecular mechanisms of the multifaceted IL‐10‐mediated anti‐inflammatory response: lessons from neutrophils
Abstract Analysis of the molecular mechanisms governing the ability of IL‐10 to keep
inflammation under control has highlighted the existence of a great degree of plasticity and …
inflammation under control has highlighted the existence of a great degree of plasticity and …
15-Deoxy-Δ12, 14-prostaglandin J2, an electrophilic lipid mediator of anti-inflammatory and pro-resolving signaling
YJ Surh, HK Na, JM Park, HN Lee, W Kim… - Biochemical …, 2011 - Elsevier
15-deoxy-Δ12, 14-prostagandin J2 (15d-PGJ2) is produced in the inflamed cells and tissues
as a consequence of upregulation of cyclooxygenase-2 (COX-2). 15d-PGJ2 is known to be …
as a consequence of upregulation of cyclooxygenase-2 (COX-2). 15d-PGJ2 is known to be …
STAT3 signaling in pulmonary arterial hypertension
R Paulin, J Meloche, S Bonnet - Jak-Stat, 2012 - Taylor & Francis
Pulmonary artery hypertension (PAH) is a proliferative disorder associated with enhanced
pulmonary artery smooth muscle cell proliferation and suppressed apoptosis. The …
pulmonary artery smooth muscle cell proliferation and suppressed apoptosis. The …
The many faces of PPARγ: anti-inflammatory by any means?
The peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear
receptor superfamily, a group of transcription factors that regulate expression of their target …
receptor superfamily, a group of transcription factors that regulate expression of their target …