EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
The success of anticancer therapy is usually limited by the development of drug resistance.
Such acquired resistance is driven, in part, by intratumoural heterogeneity—that is, the …
Such acquired resistance is driven, in part, by intratumoural heterogeneity—that is, the …
The E-cadherin and N-cadherin switch in epithelial-to-mesenchymal transition: signaling, therapeutic implications, and challenges
Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …
Targeting apoptosis in cancer
P Singh, B Lim - Current oncology reports, 2022 - Springer
Abstract Purpose of Review Apoptosis is a major mechanism of cancer cell death. Thus,
evasion of apoptosis results in therapy resistance. Here, we review apoptosis modulators in …
evasion of apoptosis results in therapy resistance. Here, we review apoptosis modulators in …
The functional activity of E-cadherin controls tumor cell metastasis at multiple steps
TY Na, L Schecterson, AM Mendonsa… - Proceedings of the …, 2020 - National Acad Sciences
E-cadherin is a tumor suppressor protein, and the loss of its expression in association with
the epithelial mesenchymal transition (EMT) occurs frequently during tumor metastasis …
the epithelial mesenchymal transition (EMT) occurs frequently during tumor metastasis …
E-cadherin: Its dysregulation in carcinogenesis and clinical implications
E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at
adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by …
adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by …
Update on epithelial-mesenchymal plasticity in cancer progression
Epithelial-mesenchymal transition (EMT) is a cellular process by which epithelial cells lose
their characteristics and acquire mesenchymal traits to promote cell movement. This …
their characteristics and acquire mesenchymal traits to promote cell movement. This …
Regulation of epithelial-mesenchymal transition by tumor microenvironmental signals and its implication in cancer therapeutics
Epithelial–mesenchymal transition (EMT) has been implicated in various aspects of tumor
development, including tumor invasion and metastasis, cancer stemness, and therapy …
development, including tumor invasion and metastasis, cancer stemness, and therapy …
Regulated cell death: signaling and mechanisms
Cell turnover is a fundamental feature in metazoans. Cells can die passively, as a
consequence of severe damage to their structural integrity, or actively, owing to a more …
consequence of severe damage to their structural integrity, or actively, owing to a more …
Targeting the extrinsic apoptotic pathway in cancer: lessons learned and future directions
A Ashkenazi - The Journal of clinical investigation, 2015 - Am Soc Clin Investig
Apoptosis is a metazoan process of controlled cell elimination that plays critical roles in
embryonic development and adult tissue homeostasis. Apoptosis dysregulation contributes …
embryonic development and adult tissue homeostasis. Apoptosis dysregulation contributes …
[HTML][HTML] P120 and E-cadherin: Double-edged swords in tumor metastasis
JH Venhuizen, FJC Jacobs, PN Span… - Seminars in cancer …, 2020 - Elsevier
Cell-cell adhesion by adherens junctions controls proliferation and cell polarization and is
crucial to maintain epithelial architecture and homeostasis. Downregulation of two of the …
crucial to maintain epithelial architecture and homeostasis. Downregulation of two of the …