The transmission of a complete set of chromosomes to daughter cells during cell division is
vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) …

Cancer is a group of diseases in which cells divide continuously and excessively. Cell
division is tightly regulated by multiple evolutionarily conserved cell cycle control …

Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …

The spindle assembly checkpoint (SAC) is a surveillance mechanism that promotes
accurate chromosome segregation in mitosis. The checkpoint senses the attachment state of …

The spindle assembly checkpoint is a safeguard mechanism that coordinates cell-cycle
progression during mitosis with the state of chromosome attachment to the mitotic spindle …

During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome
stability by delaying cell division until accurate chromosome segregation can be …

Taxol®, an antitumor drug with significant activity, is the first microtubule stabilizing agent
described in the literature. This short review of the mechanism of action of Taxol® …

Major currently used anticancer therapeutics either directly damage DNA or target and upset
basic cell division mechanisms like DNA replication and chromosome segregation. These …

In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore,
a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches …

In eukaryotes, the spindle-assembly checkpoint (SAC) is a ubiquitous safety device that
ensures the fidelity of chromosome segregation in mitosis. The SAC prevents chromosome …