Haematopoietic stem cell activity and interactions with the niche
The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …
The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies
H Zhang, JL Liesveld, LM Calvi, BC Lipe, L **ng… - Bone Research, 2023 - nature.com
Prior research establishing that bone interacts in coordination with the bone marrow
microenvironment (BMME) to regulate hematopoietic homeostasis was largely based on …
microenvironment (BMME) to regulate hematopoietic homeostasis was largely based on …
[HTML][HTML] The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance
Our study details the stepwise evolution of gilteritinib resistance in FLT3-mutated acute
myeloid leukemia (AML). Early resistance is mediated by the bone marrow …
myeloid leukemia (AML). Early resistance is mediated by the bone marrow …
Leukemic stem cells: from leukemic niche biology to treatment opportunities
Acute myeloid leukemia (AML) is one of the most common types of leukemia in adults. While
complete remission can be obtained with intensive chemotherapy in young and fit patients …
complete remission can be obtained with intensive chemotherapy in young and fit patients …
Dynamic responses of the haematopoietic stem cell niche to diverse stresses
Adult haematopoietic stem cells (HSCs) mainly reside in the bone marrow, where stromal
and haematopoietic cells regulate their function. The steady state HSC niche has been …
and haematopoietic cells regulate their function. The steady state HSC niche has been …
The cytokine network in acute myeloid leukemia
Acute myeloid leukemia (AML) is a highly heterogeneous malignancy of the blood and bone
marrow, characterized by clonal expansion of myeloid stem and progenitor cells and rapid …
marrow, characterized by clonal expansion of myeloid stem and progenitor cells and rapid …
[HTML][HTML] Pathophysiology of acute myeloid leukemia
Background: Acute myeloid leukemia (AML) is a biologically heterogenous disease arising
in clonally proliferating hematopoietic stem cells. Sequential acquisition of mutations leads …
in clonally proliferating hematopoietic stem cells. Sequential acquisition of mutations leads …
[HTML][HTML] Cancer metastases to bone: concepts, mechanisms, and interactions with bone osteoblasts
AB Shupp, AD Kolb, D Mukhopadhyay, KM Bussard - Cancers, 2018 - mdpi.com
The skeleton is a unique structure capable of providing support for the body. Bone
resorption and deposition are controlled in a tightly regulated balance between osteoblasts …
resorption and deposition are controlled in a tightly regulated balance between osteoblasts …
Bone marrow mesenchymal stromal cells from acute myelogenous leukemia patients demonstrate adipogenic differentiation propensity with implications for leukemia …
Bone marrow mesenchymal stromal cells (MSCs) constitute one of the important
components of the hematopoietic microenvironmental niche. In vivo studies have shown that …
components of the hematopoietic microenvironmental niche. In vivo studies have shown that …
Acute myeloid leukemia and the bone marrow niche—take a closer look
L Behrmann, J Wellbrock, W Fiedler - Frontiers in oncology, 2018 - frontiersin.org
The bone marrow is the home of hematopoiesis and is therefore a hotspot for the
development of hematopoietic diseases. Complex interactions between the bone marrow …
development of hematopoietic diseases. Complex interactions between the bone marrow …