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Dynamics of mature myelin
Myelin, which is produced by oligodendrocytes, insulates axons to facilitate rapid and
efficient action potential propagation in the central nervous system. Traditionally viewed as a …
efficient action potential propagation in the central nervous system. Traditionally viewed as a …
MWF of the corpus callosum is a robust measure of remyelination: Results from the ReBUILD trial
Myelin repair is an unrealized therapeutic goal in the treatment of multiple sclerosis (MS).
Uncertainty remains about the optimal techniques for assessing therapeutic efficacy and …
Uncertainty remains about the optimal techniques for assessing therapeutic efficacy and …
Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis
MM Poon, KI Lorrain, KJ Stebbins, GC Edu… - Proceedings of the …, 2024 - pnas.org
Multiple sclerosis (MS) is a chronic and debilitating neurological disease that results in
inflammatory demyelination. While endogenous remyelination helps to recover function, this …
inflammatory demyelination. While endogenous remyelination helps to recover function, this …
Targeting cell membranes, depleting ROS by dithiane and thioketal-containing polymers with pendant cholesterols delivering necrostatin-1 for glaucoma treatment
Glaucoma is the leading cause of irreversible blindness worldwide, characterized by
progressive vision loss due to the selective damage to retinal ganglion cells (RGCs) and …
progressive vision loss due to the selective damage to retinal ganglion cells (RGCs) and …
Remyelination in animal models of multiple sclerosis: finding the elusive grail of regeneration
Remyelination biology and the therapeutic potential of restoring myelin sheaths to prevent
neurodegeneration and disability in multiple sclerosis (MS) has made considerable gains …
neurodegeneration and disability in multiple sclerosis (MS) has made considerable gains …
Synaptic injury in the inner plexiform layer of the retina is associated with progression in multiple sclerosis
While neurodegeneration underlies the pathological basis for permanent disability in
multiple sclerosis (MS), predictive biomarkers for progression are lacking. Using an animal …
multiple sclerosis (MS), predictive biomarkers for progression are lacking. Using an animal …
Remyelination protects neurons from DLK-mediated neurodegeneration
Chronic demyelination and oligodendrocyte loss deprive neurons of crucial support. It is the
degeneration of neurons and their connections that drives progressive disability in …
degeneration of neurons and their connections that drives progressive disability in …
Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function
Myelin loss induces neural dysfunction and contributes to the pathophysiology of
neurodegenerative diseases, injury conditions, and aging. Because remyelination is often …
neurodegenerative diseases, injury conditions, and aging. Because remyelination is often …
Prolonged myelin deficits contribute to neuron loss and functional impairments after ischaemic stroke
YJ Cheng, F Wang, J Feng, B Yu, B Wang, Q Gao… - Brain, 2024 - academic.oup.com
Ischaemic stroke causes neuron loss and long-term functional deficits. Unfortunately,
effective approaches to preserving neurons and promoting functional recovery remain …
effective approaches to preserving neurons and promoting functional recovery remain …
Discovery of a brain penetrant small molecule antagonist targeting LPA1 receptors to reduce neuroinflammation and promote remyelination in multiple sclerosis
MM Poon, KI Lorrain, KJ Stebbins, GC Edu… - Scientific Reports, 2024 - nature.com
Multiple sclerosis (MS) is a chronic neurological disease characterized by inflammatory
demyelination that disrupts neuronal transmission resulting in neurodegeneration …
demyelination that disrupts neuronal transmission resulting in neurodegeneration …