The widespread occurrence of repetitive stretches of DNA in genomes of organisms across
the tree of life imposes fundamental challenges for sequencing, genome assembly, and …

Simple Summary Due to the development of high-throughput sequencing technologies,
computational genome annotation of sequences has become one of the principal research …

The human Y chromosome has been notoriously difficult to sequence and assemble
because of its complex repeat structure that includes long palindromes, tandem repeats and …

Methods for evaluating the quality of genomic and metagenomic data are essential to aid
genome assembly procedures and to correctly interpret the results of subsequent analyses …

Since its initial release in 2000, the human reference genome has covered only the
euchromatic fraction of the genome, leaving important heterochromatic regions unfinished …

Conifers dominate the world's forest ecosystems and are the most widely planted tree
species. Their giant and complex genomes present great challenges for assembling a …

The task of eukaryotic genome annotation remains challenging. Only a few genomes could
serve as standards of annotation achieved through a tremendous investment of human …

Gene prediction has remained an active area of bioinformatics research for a long time. Still,
gene prediction in large eukaryotic genomes presents a challenge that must be addressed …

Broomcorn millet (Panicum miliaceum L.) is an orphan crop with the potential to improve
cereal production and quality, and ensure food security. Here we present the genetic …

In the context of climate change, drought is one of the most limiting factors that influence
crop production. Maize, as a major crop, is highly vulnerable to water deficit, which causes …