Tryptophan synthase: a multienzyme complex with an intramolecular tunnel
EW Miles - The Chemical Record, 2001 - Wiley Online Library
Tryptophan synthase is a classic enzyme that channels a metabolic intermediate, indole.
The crystal structure of the tryptophan synthase α2β2 complex from Salmonella typhimurium …
The crystal structure of the tryptophan synthase α2β2 complex from Salmonella typhimurium …
Tryptophan synthase: a mine for enzymologists
Tryptophan synthase is a pyridoxal 5′-phosphate-dependent α 2 β 2 complex catalyzing
the last two steps of tryptophan biosynthesis in bacteria, plants and fungi. Structural …
the last two steps of tryptophan biosynthesis in bacteria, plants and fungi. Structural …
Loop Closure and Intersubunit Communication in Tryptophan Synthase,
Crystal structures of wild-type tryptophan synthase α2β2 complexes from Salmonella
typhimurium were determined to investigate the mechanism of allosteric activation of the α …
typhimurium were determined to investigate the mechanism of allosteric activation of the α …
Domain architecture of the heme-independent yeast cystathionine β-synthase provides insights into mechanisms of catalysis and regulation
KH Jhee, P McPhie, EW Miles - Biochemistry, 2000 - ACS Publications
Cystathionine β-synthase from yeast (Saccharomyces cerevisiae) provides a model system
for understanding some of the effects of disease-causing mutations in the human enzyme …
for understanding some of the effects of disease-causing mutations in the human enzyme …
Protonation states of the tryptophan synthase internal aldimine active site from solid-state NMR spectroscopy: direct observation of the protonated Schiff base linkage …
The acid–base chemistry that drives catalysis in pyridoxal-5′-phosphate (PLP)-dependent
enzymes has been the subject of intense interest and investigation since the initial …
enzymes has been the subject of intense interest and investigation since the initial …
Pyridoxal 5′-phosphate-dependent enzymes at the crossroads of host–microbe tryptophan metabolism
The chemical processes taking place in humans intersects the myriad of metabolic pathways
occurring in commensal microorganisms that colonize the body to generate a complex …
occurring in commensal microorganisms that colonize the body to generate a complex …
Exploring and exploiting allostery: Models, evolution, and drug targeting
The concept of allostery was elaborated almost 50years ago by Monod and coworkers to
provide a framework for interpreting experimental studies on the regulation of protein …
provide a framework for interpreting experimental studies on the regulation of protein …
Cooperative fluctuations and subunit communication in tryptophan synthase
Tryptophan synthase (TRPS), with linearly arrayed subunits αββα, catalyzes the last two
reactions in the biosynthesis of l-tryptophan. The two reactions take place in the respective α …
reactions in the biosynthesis of l-tryptophan. The two reactions take place in the respective α …
The enzymology of cystathionine biosynthesis: strategies for the control of substrate and reaction specificity
SM Aitken, JF Kirsch - Archives of biochemistry and biophysics, 2005 - Elsevier
The ability of enzymes to catalyze specific reactions, while excluding others, is central to
cellular metabolism. Control of reaction specificity is of particular importance for enzymes …
cellular metabolism. Control of reaction specificity is of particular importance for enzymes …
Allosteric regulation of substrate channeling: Salmonella typhimurium tryptophan synthase
The regulation of the synthesis of L-tryptophan (L-Trp) in enteric bacteria begins at the level
of gene expression where the cellular concentration of L-Trp tightly controls expression of …
of gene expression where the cellular concentration of L-Trp tightly controls expression of …