Mechanical state transitions in the regulation of tissue form and function
From embryonic development, postnatal growth and adult homeostasis to reparative and
disease states, cells and tissues undergo constant changes in genome activity, cell fate …
disease states, cells and tissues undergo constant changes in genome activity, cell fate …
From WRC to Arp2/3: Collective molecular mechanisms of branched actin network assembly
Branched actin networks have emerged as major force-generating structures driving the
protrusions in various distinct cell types and processes, ranging from lamellipodia operating …
protrusions in various distinct cell types and processes, ranging from lamellipodia operating …
Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments
The release of inorganic phosphate (Pi) from actin filaments constitutes a key step in their
regulated turnover, which is fundamental to many cellular functions. The mechanisms …
regulated turnover, which is fundamental to many cellular functions. The mechanisms …
Synthetic, multi-dynamic hydrogels by uniting stress-stiffening and supramolecular polymers
Nature uses discrete molecular building blocks to form polymers that assemble into
multicomponent, multi-dynamic networks, inside (cytoskeleton) and outside (extracellular …
multicomponent, multi-dynamic networks, inside (cytoskeleton) and outside (extracellular …
Multicomponent regulation of actin barbed end assembly by twinfilin, formin and cap** protein
Cells control actin assembly by regulating reactions at actin filament barbed ends. Formins
accelerate elongation, cap** protein (CP) arrests growth and twinfilin promotes …
accelerate elongation, cap** protein (CP) arrests growth and twinfilin promotes …
Structures and mechanisms of actin ATP hydrolysis
The major cytoskeleton protein actin undergoes cyclic transitions between the monomeric G-
form and the filamentous F-form, which drive organelle transport and cell motility. This …
form and the filamentous F-form, which drive organelle transport and cell motility. This …
Phalloidin and DNase I-bound F-actin pointed end structures reveal principles of filament stabilization and disassembly
M Boiero Sanders, W Oosterheert, O Hofnagel… - Nature …, 2024 - nature.com
Actin filament turnover involves subunits binding to and dissociating from the filament ends,
with the pointed end being the primary site of filament disassembly. Several molecules …
with the pointed end being the primary site of filament disassembly. Several molecules …
Mitochondria-and ER-associated actin are required for mitochondrial fusion
P Gatti, C Schiavon, J Cicero, U Manor… - Nature …, 2025 - nature.com
Mitochondria are crucial for cellular metabolism and signalling. Mitochondrial activity is
modulated by mitochondrial fission and fusion, which are required to properly balance …
modulated by mitochondrial fission and fusion, which are required to properly balance …
Regeneration of actin filament branches from the same Arp2/3 complex
F Ghasemi, LY Cao, M Mladenov, B Guichard… - Science …, 2024 - science.org
Branched actin filaments are found in many key cellular structures. Branches are nucleated
by the Arp2/3 complex activated by nucleation-promoting factor (NPF) proteins and bound to …
by the Arp2/3 complex activated by nucleation-promoting factor (NPF) proteins and bound to …
Regulation of branched versus linear Arp2/3‐generated actin filaments
Activation of the Arp2/3 complex by VCA‐motif‐bearing actin nucleation‐promoting factors
results in the formation of “daughter” actin filaments branching off the sides of pre‐existing …
results in the formation of “daughter” actin filaments branching off the sides of pre‐existing …