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The involvement of the oxidative stress status in cancer pathology: A double view on the role of the antioxidants
Oxygen‐free radicals, reactive oxygen species (ROS) or reactive nitrogen species (RNS),
are known by their “double‐sided” nature in biological systems. The beneficial effects of …
are known by their “double‐sided” nature in biological systems. The beneficial effects of …
Life and death: metabolic rate, membrane composition, and life span of animals
Maximum life span differences among animal species exceed life span variation achieved
by experimental manipulation by orders of magnitude. The differences in the characteristic …
by experimental manipulation by orders of magnitude. The differences in the characteristic …
Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts
An updated version of the mitochondrial free radical theory of aging (MFRTA) and longevity
is reviewed. Key aspects of the theory are emphasized. Another main focus concerns …
is reviewed. Key aspects of the theory are emphasized. Another main focus concerns …
Hyperglycemia and glycation in diabetic complications
Diabetes mellitus is a multifactorial disease, classically influenced by genetic determinants
of individual susceptibility and by environmental accelerating factors, such as lifestyle. It is …
of individual susceptibility and by environmental accelerating factors, such as lifestyle. It is …
[HTML][HTML] Membrane phospholipids, lipoxidative damage and molecular integrity: a causal role in aging and longevity
Nonenzymatic molecular modifications induced by reactive carbonyl species (RCS)
generated by peroxidation of membrane phospholipids acyl chains play a causal role in the …
generated by peroxidation of membrane phospholipids acyl chains play a causal role in the …
Mitochondrial oxidative stress plays a key role in aging and apoptosis
Harman first suggested in 1972 that mitochondria might be the biological clock in aging,
noting that the rate of oxygen consumption should determine the rate of accumulation of …
noting that the rate of oxygen consumption should determine the rate of accumulation of …
High oxidative damage levels in the longest‐living rodent, the naked mole‐rat
Oxidative stress is reputed to be a significant contributor to the aging process and a key
factor affecting species longevity. The tremendous natural variation in maximum species …
factor affecting species longevity. The tremendous natural variation in maximum species …
[HTML][HTML] Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection
Caloric restriction (CR) decreases aging rate and mitochondrial ROS (MitROS) production
and oxidative stress in rat postmitotic tissues. Low levels of these parameters are also typical …
and oxidative stress in rat postmitotic tissues. Low levels of these parameters are also typical …
Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span: a homeoviscous‐longevity adaptation?
Aging is a progressive and universal process originating endogenously that manifests
during postmaturational life. Available comparative evidence supporting the mitochondrial …
during postmaturational life. Available comparative evidence supporting the mitochondrial …
Lipidomics of familial longevity
Middle‐aged offspring of nonagenarians, as compared to their spouses (controls), show a
favorable lipid metabolism marked by larger LDL particle size in men and lower total …
favorable lipid metabolism marked by larger LDL particle size in men and lower total …