Physical principles of nanoparticle cellular endocytosis
This review article focuses on the physiochemical mechanisms underlying nanoparticle
uptake into cells. When nanoparticles are in close vicinity to a cell, the interactions between …
uptake into cells. When nanoparticles are in close vicinity to a cell, the interactions between …
Fluid lipid membranes: From differential geometry to curvature stresses
M Deserno - Chemistry and physics of lipids, 2015 - Elsevier
A fluid lipid membrane transmits stresses and torques that are fully determined by its
geometry. They can be described by a stress-and torque-tensor, respectively, which yield …
geometry. They can be described by a stress-and torque-tensor, respectively, which yield …
Receptor-mediated endocytosis of nanoparticles of various shapes
Cellular uptake through endocytosis is crucial for drug delivery and nanomedicine.
However, the conditions under which passive endocytosis (ie, not ATP driven) takes place …
However, the conditions under which passive endocytosis (ie, not ATP driven) takes place …
Spontaneous curvature, differential stress, and bending modulus of asymmetric lipid membranes
Lipid bilayers can exhibit asymmetric states, in which the physical characteristics of one
leaflet differ from those of the other. This most visibly manifests in a different lipid …
leaflet differ from those of the other. This most visibly manifests in a different lipid …
Membrane wrap** efficiency of elastic nanoparticles during endocytosis: size and shape matter
Using coarse-grained molecular dynamics simulations, we systematically investigate the
receptor-mediated endocytosis of elastic nanoparticles (NPs) with different sizes, ranging …
receptor-mediated endocytosis of elastic nanoparticles (NPs) with different sizes, ranging …
[HTML][HTML] Lipids on the move: simulations of membrane pores, domains, stalks and curves
In this review we describe the state-of-the-art of computer simulations studies of lipid
membranes. We focus on collective lipid–lipid and lipid–protein interactions that trigger …
membranes. We focus on collective lipid–lipid and lipid–protein interactions that trigger …
Lipid shape and packing are key for optimal design of pH-sensitive mRNA lipid nanoparticles
The ionizable-lipid component of RNA-containing nanoparticles controls the pH-dependent
behavior necessary for an efficient delivery of the cargo—the so-called endosomal escape …
behavior necessary for an efficient delivery of the cargo—the so-called endosomal escape …
Role of nanoparticle geometry in endocytosis: laying down to stand up
Nanoparticles (NPs) hold great promises for targeted disease diagnosis and therapy.
Despite considerable progress in biomimetic design of NP-bioconjugates, the roles of NP …
Despite considerable progress in biomimetic design of NP-bioconjugates, the roles of NP …
[HTML][HTML] Rational design of liposomal drug delivery systems, a review: Combined experimental and computational studies of lipid membranes, liposomes and their …
Combined experimental and computational studies of lipid membranes and liposomes, with
the aim to attain mechanistic understanding, result in a synergy that makes possible the …
the aim to attain mechanistic understanding, result in a synergy that makes possible the …
Microfluidic synthesis of hybrid nanoparticles with controlled lipid layers: understanding flexibility-regulated cell–nanoparticle interaction
The functionalized lipid shell of hybrid nanoparticles plays an important role for improving
their biocompatibility and in vivo stability. Yet few efforts have been made to critically …
their biocompatibility and in vivo stability. Yet few efforts have been made to critically …