Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …

The kainic acid model of temporal lobe epilepsy has greatly contributed to the
understanding of the molecular, cellular and pharmacological mechanisms underlying …

This review focuses on the remodeling of brain circuitry associated with epilepsy, particularly
in excitatory glutamate and inhibitory GABA systems, including alterations in synaptic …

Experimental models of epilepsy are useful to identify potential mechanisms of
epileptogenesis, seizure genesis, comorbidities, and treatment efficacy. The kainic acid (KA) …

In order to understand the pathophysiology of temporal lobe epilepsy (TLE), and thus to
develop new pharmacological treatments, in vivo animal models that present features …

Inflammation is an important factor in the pathophysiology of seizure generation and
epileptogenesis. While the role of CNS inflammation is well acknowledged as an important …

Mesial temporal lobe epilepsy (MTLE), the most common epilepsy in adults, is generally
intractable and is suspected to be the result of recurrent excitation or inhibition circuitry …

The hippocampus is typically described in the context of the trisynaptic circuit, a pathway that
relays information from the perforant path to the dentate gyrus, dentate to area CA3, and …

In childhood, the risk for seizures is greatest in the neonatal period. Currently used therapies
have limited efficacy. Although the treatment of neonatal seizures has not significantly …

In adult rats, status epilepticus (SE) induces cytokine production by glia especially when
seizures are associated with neuronal injury. This suggests that cytokines may play a role in …