While the energy landscape theory of protein folding is now a widely accepted view for
understanding how relatively weak molecular interactions lead to rapid and cooperative …

Ribosomal proteins are fundamental components of the ribosomes in all living cells. The
ribosomal protein uS5 (Rps2) is a stable component of the small ribosomal subunit within all …

Acne vulgaris is a chronic disfiguring skin disease affecting∼ 1 billion people worldwide,
often having persistent negative effects on physical and mental health. The Gram-positive …

Nascent-peptide modulation of translation is a common regulatory mechanism of gene
expression. In this mechanism, while the nascent peptide is still in the exit tunnel of the …

Alternative ribosome subunit proteins are prevalent in the genomes of diverse bacterial
species, but their functional significance is controversial. Attempts to study microbial …

Functional rearrangements in biomolecular assemblies result from diffusion across an
underlying energy landscape. While bulk kinetic measurements rely on discrete state-like …

Single-stranded DNA-binding proteins (SSBs) play vital roles in DNA metabolism. Proteins
of the SSB family exclusively and transiently bind to ssDNA, preventing the DNA double …

Fluctuations of protein three-dimensional structures and large-scale conformational
transitions are crucial for the biological function of proteins and their complexes …

Coarse-grained (CG) models of large biomolecular complexes enable simulations of these
systems over long timescales that are not accessible for atomistic molecular dynamics (MD) …

Ribosomes are the dynamic protein synthesis machineries of the cell. They may exist in
different functional states in the cell. Therefore, it is essential to have structural information …